| pubmed-article:10640272 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10640272 | lifeskim:mentions | umls-concept:C0013935 | lld:lifeskim |
| pubmed-article:10640272 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:10640272 | lifeskim:mentions | umls-concept:C1366587 | lld:lifeskim |
| pubmed-article:10640272 | lifeskim:mentions | umls-concept:C0011155 | lld:lifeskim |
| pubmed-article:10640272 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10640272 | pubmed:dateCreated | 2000-2-15 | lld:pubmed |
| pubmed-article:10640272 | pubmed:abstractText | We disrupted the Mcl-1 locus in murine ES cells to determine the developmental roles of this Bcl-2 family member. Deletion of Mcl-1 resulted in peri-implantation embryonic lethality. Mcl-1(-/-) embryos do not implant in utero, but could be recovered at E3.5-4.0. Null blastocysts failed to hatch or attach in vitro, indicating a trophectoderm defect, although the inner cell mass could grow in culture. Of note, Mcl-1(-/-) blastocysts showed no evidence of increased apoptosis, but exhibited a delay in maturation beyond the precompaction stage. This model indicates that Mcl-1 is essential for preimplantation development and implantation, and suggests that it has a function beyond regulating apoptosis. | lld:pubmed |
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| pubmed-article:10640272 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10640272 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10640272 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10640272 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10640272 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:10640272 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:10640272 | pubmed:author | pubmed-author:RothKK | lld:pubmed |
| pubmed-article:10640272 | pubmed:author | pubmed-author:KorsmeyerS... | lld:pubmed |
| pubmed-article:10640272 | pubmed:author | pubmed-author:KlockeBB | lld:pubmed |
| pubmed-article:10640272 | pubmed:author | pubmed-author:RinkenbergerJ... | lld:pubmed |
| pubmed-article:10640272 | pubmed:author | pubmed-author:HorningSS | lld:pubmed |
| pubmed-article:10640272 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10640272 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10640272 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:10640272 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10640272 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10640272 | pubmed:pagination | 23-7 | lld:pubmed |
| pubmed-article:10640272 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:10640272 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10640272 | pubmed:articleTitle | Mcl-1 deficiency results in peri-implantation embryonic lethality. | lld:pubmed |
| pubmed-article:10640272 | pubmed:affiliation | Departments of Medicine and Pathology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, Missouri 63110 USA. | lld:pubmed |
| pubmed-article:10640272 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10640272 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10640272 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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