| pubmed-article:10637298 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10637298 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:10637298 | lifeskim:mentions | umls-concept:C0030498 | lld:lifeskim |
| pubmed-article:10637298 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:10637298 | lifeskim:mentions | umls-concept:C0521447 | lld:lifeskim |
| pubmed-article:10637298 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:10637298 | lifeskim:mentions | umls-concept:C0041221 | lld:lifeskim |
| pubmed-article:10637298 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:10637298 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:10637298 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10637298 | pubmed:dateCreated | 2000-4-7 | lld:pubmed |
| pubmed-article:10637298 | pubmed:abstractText | The transcription factor nuclear factor-kappaB (NF-kappaB) is central to the innate and acquired immune response to microbial pathogens, coordinating cellular responses to the presence of infection. Here we demonstrate a direct role for NF-kappaB activation in controlling intracellular infection in nonimmune cells. Trypanosoma cruzi is an intracellular parasite of mammalian cells with a marked preference for infection of myocytes. The molecular basis for this tissue tropism is unknown. Trypomastigotes, the infectious stage of T. cruzi, activate nuclear translocation and DNA binding of NF-kappaB p65 subunit and NF-kappaB-dependent gene expression in epithelial cells, endothelial cells, and fibroblasts. Inactivation of epithelial cell NF-kappaB signaling by inducible expression of the inhibitory mutant IkappaBaM significantly enhances parasite invasion. T. cruzi do not activate NF-kappaB in cells derived from skeletal, smooth, or cardiac muscle, despite the ability of these cells to respond to tumor necrosis factor-alpha with NF-kappaB activation. The in vitro infection level in these muscle-derived cells is more than double that seen in the other cell types tested. Therefore, the ability of T. cruzi to activate NF-kappaB correlates inversely with susceptibility to infection, suggesting that NF-kappaB activation is a determinant of the intracellular survival and tissue tropism of T. cruzi. | lld:pubmed |
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| pubmed-article:10637298 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10637298 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10637298 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10637298 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10637298 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:10637298 | pubmed:issn | 1059-1524 | lld:pubmed |
| pubmed-article:10637298 | pubmed:author | pubmed-author:PereiraM EME | lld:pubmed |
| pubmed-article:10637298 | pubmed:author | pubmed-author:SenRR | lld:pubmed |
| pubmed-article:10637298 | pubmed:author | pubmed-author:TamWW | lld:pubmed |
| pubmed-article:10637298 | pubmed:author | pubmed-author:HallB SBS | lld:pubmed |
| pubmed-article:10637298 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10637298 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:10637298 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10637298 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10637298 | pubmed:pagination | 153-60 | lld:pubmed |
| pubmed-article:10637298 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:10637298 | pubmed:meshHeading | pubmed-meshheading:10637298... | lld:pubmed |
| pubmed-article:10637298 | pubmed:meshHeading | pubmed-meshheading:10637298... | lld:pubmed |
| pubmed-article:10637298 | pubmed:meshHeading | pubmed-meshheading:10637298... | lld:pubmed |
| pubmed-article:10637298 | pubmed:meshHeading | pubmed-meshheading:10637298... | lld:pubmed |
| pubmed-article:10637298 | pubmed:meshHeading | pubmed-meshheading:10637298... | lld:pubmed |
| pubmed-article:10637298 | pubmed:meshHeading | pubmed-meshheading:10637298... | lld:pubmed |
| pubmed-article:10637298 | pubmed:meshHeading | pubmed-meshheading:10637298... | lld:pubmed |
| pubmed-article:10637298 | pubmed:meshHeading | pubmed-meshheading:10637298... | lld:pubmed |
| pubmed-article:10637298 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10637298 | pubmed:articleTitle | Cell-specific activation of nuclear factor-kappaB by the parasite Trypanosoma cruzi promotes resistance to intracellular infection. | lld:pubmed |
| pubmed-article:10637298 | pubmed:affiliation | Parasitology Research Center, Department of Pathology, Tufts University Medical School, Boston, Massachusetts 02111, USA. | lld:pubmed |
| pubmed-article:10637298 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10637298 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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