| pubmed-article:10617600 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10617600 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10617600 | lifeskim:mentions | umls-concept:C0005821 | lld:lifeskim |
| pubmed-article:10617600 | lifeskim:mentions | umls-concept:C0003942 | lld:lifeskim |
| pubmed-article:10617600 | lifeskim:mentions | umls-concept:C0597538 | lld:lifeskim |
| pubmed-article:10617600 | lifeskim:mentions | umls-concept:C0720298 | lld:lifeskim |
| pubmed-article:10617600 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10617600 | pubmed:dateCreated | 2000-1-31 | lld:pubmed |
| pubmed-article:10617600 | pubmed:abstractText | We have investigated the ability of alkylphenols to act as substrates and/or inhibitors of phenol sulfotransferase enzymes in human platelet cytosolic fractions. Our results indicate: (i) straight chain alkylphenols do not interact with the monoamine-sulfating phenol sulfotransferase (SULT1A3); (ii) short chain 4-n-alkylphenols (C < 8) are substrates for the phenol-sulfating enzymes (SULT1A1/2), which exhibit two activity maxima against substrates with alkyl chain lengths of C1-2 and C4-5; (iii) long chain 4-n-substituted alkylphenols (C >/= 8) are poor substrates and act as inhibitors of SULT1A1/2; (iv) human platelets contain two activities, of low and high affinity, capable of sulfating 17beta-estradiol, and 4-n-nonylphenol is a partial mixed inhibitor of the low affinity form of this activity. We conclude that by acting either as substrates or inhibitors of SULT1A1/2, alkylphenols may influence the sulfation, and hence the excretion, of estrogens and other phenol sulfotransferase substrates in humans. | lld:pubmed |
| pubmed-article:10617600 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10617600 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10617600 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10617600 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10617600 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10617600 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10617600 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10617600 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10617600 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10617600 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10617600 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10617600 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10617600 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10617600 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10617600 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:10617600 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:10617600 | pubmed:author | pubmed-author:KirkC JCJ | lld:pubmed |
| pubmed-article:10617600 | pubmed:author | pubmed-author:WaringR HRH | lld:pubmed |
| pubmed-article:10617600 | pubmed:author | pubmed-author:HarrisR MRM | lld:pubmed |
| pubmed-article:10617600 | pubmed:author | pubmed-author:HughesP JPJ | lld:pubmed |
| pubmed-article:10617600 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10617600 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:10617600 | pubmed:volume | 275 | lld:pubmed |
| pubmed-article:10617600 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10617600 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10617600 | pubmed:pagination | 159-66 | lld:pubmed |
| pubmed-article:10617600 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:10617600 | pubmed:meshHeading | pubmed-meshheading:10617600... | lld:pubmed |
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| pubmed-article:10617600 | pubmed:meshHeading | pubmed-meshheading:10617600... | lld:pubmed |
| pubmed-article:10617600 | pubmed:meshHeading | pubmed-meshheading:10617600... | lld:pubmed |
| pubmed-article:10617600 | pubmed:meshHeading | pubmed-meshheading:10617600... | lld:pubmed |
| pubmed-article:10617600 | pubmed:meshHeading | pubmed-meshheading:10617600... | lld:pubmed |
| pubmed-article:10617600 | pubmed:meshHeading | pubmed-meshheading:10617600... | lld:pubmed |
| pubmed-article:10617600 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10617600 | pubmed:articleTitle | Sulfation of "estrogenic" alkylphenols and 17beta-estradiol by human platelet phenol sulfotransferases. | lld:pubmed |
| pubmed-article:10617600 | pubmed:affiliation | School of Biosciences, the University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom. | lld:pubmed |
| pubmed-article:10617600 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10617600 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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