| pubmed-article:10605951 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10605951 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:10605951 | lifeskim:mentions | umls-concept:C0032176 | lld:lifeskim |
| pubmed-article:10605951 | lifeskim:mentions | umls-concept:C0010592 | lld:lifeskim |
| pubmed-article:10605951 | lifeskim:mentions | umls-concept:C0205100 | lld:lifeskim |
| pubmed-article:10605951 | lifeskim:mentions | umls-concept:C0857121 | lld:lifeskim |
| pubmed-article:10605951 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:10605951 | pubmed:dateCreated | 2000-3-1 | lld:pubmed |
| pubmed-article:10605951 | pubmed:abstractText | Cyclosporin A plays an important role in preventing rejection in allograft transplant recipients. However, the therapeutic use of cyclosporin A is associated with increased incidence of thromboembolic complications and drug-related hypertension. In order to study the mechanisms by which cyclosporin A induces these abnormal pathophysiological situations, we have assessed the platelet serotonin contents and whole blood platelet aggregation in control rats as well as in rats treated (orally) with 30 and 5 mg/kg/day of cyclosporin A, after 2 and 7 weeks of treatment. These doses correspond respectively to CsA "peak" and "trough" concentrations achieved in human blood in clinical practice (immediately following an intake of a daily dose of CsA and when the blood concentration stabilizes, respectively). Both trough and peak doses caused an increase in blood pressure after 2 and 7 weeks. Platelet serotonin content decreased in the cyclosporin-treated groups, in contrast with the control. Collagen-induced whole blood platelet aggregation increased drastically for the peak concentration-treated group, while adenosine 5'-diphosphate-induced platelet aggregation did not reach statistical significance. Finally, in vitro platelet thromboxane A2 generation increased in cyclosporin A concentrations when platelets were stimulated with either collagen or adenosine 5'-diphosphate. In conclusion, both tested cyclosporin A concentrations induced important changes in platelet serotonin and thromboxane content and aggregation, factors which may play a decisive role in the development and/or maintenance of hypertension and thrombotic complications. | lld:pubmed |
| pubmed-article:10605951 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10605951 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10605951 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10605951 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10605951 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10605951 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10605951 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10605951 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10605951 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10605951 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:10605951 | pubmed:issn | 0049-3848 | lld:pubmed |
| pubmed-article:10605951 | pubmed:author | pubmed-author:TeixeiraFF | lld:pubmed |
| pubmed-article:10605951 | pubmed:author | pubmed-author:ReisFF | lld:pubmed |
| pubmed-article:10605951 | pubmed:author | pubmed-author:TavaresPP | lld:pubmed |
| pubmed-article:10605951 | pubmed:author | pubmed-author:AntunesFF | lld:pubmed |
| pubmed-article:10605951 | pubmed:author | pubmed-author:Fontes... | lld:pubmed |
| pubmed-article:10605951 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10605951 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10605951 | pubmed:volume | 96 | lld:pubmed |
| pubmed-article:10605951 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10605951 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10605951 | pubmed:pagination | 365-72 | lld:pubmed |
| pubmed-article:10605951 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:10605951 | pubmed:meshHeading | pubmed-meshheading:10605951... | lld:pubmed |
| pubmed-article:10605951 | pubmed:meshHeading | pubmed-meshheading:10605951... | lld:pubmed |
| pubmed-article:10605951 | pubmed:meshHeading | pubmed-meshheading:10605951... | lld:pubmed |
| pubmed-article:10605951 | pubmed:meshHeading | pubmed-meshheading:10605951... | lld:pubmed |
| pubmed-article:10605951 | pubmed:meshHeading | pubmed-meshheading:10605951... | lld:pubmed |
| pubmed-article:10605951 | pubmed:meshHeading | pubmed-meshheading:10605951... | lld:pubmed |
| pubmed-article:10605951 | pubmed:meshHeading | pubmed-meshheading:10605951... | lld:pubmed |
| pubmed-article:10605951 | pubmed:meshHeading | pubmed-meshheading:10605951... | lld:pubmed |
| pubmed-article:10605951 | pubmed:meshHeading | pubmed-meshheading:10605951... | lld:pubmed |
| pubmed-article:10605951 | pubmed:meshHeading | pubmed-meshheading:10605951... | lld:pubmed |
| pubmed-article:10605951 | pubmed:meshHeading | pubmed-meshheading:10605951... | lld:pubmed |
| pubmed-article:10605951 | pubmed:meshHeading | pubmed-meshheading:10605951... | lld:pubmed |
| pubmed-article:10605951 | pubmed:meshHeading | pubmed-meshheading:10605951... | lld:pubmed |
| pubmed-article:10605951 | pubmed:meshHeading | pubmed-meshheading:10605951... | lld:pubmed |
| pubmed-article:10605951 | pubmed:meshHeading | pubmed-meshheading:10605951... | lld:pubmed |
| pubmed-article:10605951 | pubmed:meshHeading | pubmed-meshheading:10605951... | lld:pubmed |
| pubmed-article:10605951 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10605951 | pubmed:articleTitle | The peripheral serotonergic system and platelet aggregation in cyclosporin A-induced hypertensive rats. | lld:pubmed |
| pubmed-article:10605951 | pubmed:affiliation | Institute of Pharmacology and Experimental Therapeutics, Faculty of Medicine, Universidade de Coimbra, Portugal. | lld:pubmed |
| pubmed-article:10605951 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10605951 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10605951 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10605951 | lld:pubmed |
