| pubmed-article:10605012 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10605012 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10605012 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:10605012 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:10605012 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10605012 | lifeskim:mentions | umls-concept:C1524075 | lld:lifeskim |
| pubmed-article:10605012 | lifeskim:mentions | umls-concept:C0205148 | lld:lifeskim |
| pubmed-article:10605012 | lifeskim:mentions | umls-concept:C0599896 | lld:lifeskim |
| pubmed-article:10605012 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:10605012 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:10605012 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:10605012 | lifeskim:mentions | umls-concept:C0337112 | lld:lifeskim |
| pubmed-article:10605012 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10605012 | pubmed:dateCreated | 2000-1-19 | lld:pubmed |
| pubmed-article:10605012 | pubmed:abstractText | The surface and cytoplasmic expressions of the transducing chain (IFN-gamma R2) of the heterodimeric IFN-gamma receptor on human T lymphocytes have been investigated. We show that its surface expression is low, whereas high cytoplasmic levels are found in both resting and PHA-activated T lymphocytes. This low expression does not prevent activated T cells from responding to IFN-gamma, because it induces IFN-regulatory factor 1 expression. Low surface IFN-gamma R2 expression appears to be due to recycling between cytoplasmic stores and the cell surface, which does not depend on signals mediated by endogenous IFN-gamma, because IFN-gamma R2 surface expression is low, and its internalization is equally observed in patients with inherited IFN-gamma R1 gene deficiency and in healthy donors. Moreover, IFN-gamma R2 internalization in T lymphoblasts from healthy donors was not affected by the presence of anti-IFN-gamma-neutralizing or anti-IFN-gamma R1-blocking mAb. In conclusion, these data illustrate a new mechanism whereby human T cells limit the surface expression of IFN-gamma R2 in a ligand-independent manner. | lld:pubmed |
| pubmed-article:10605012 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10605012 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10605012 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:10605012 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10605012 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10605012 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10605012 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10605012 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10605012 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10605012 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10605012 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10605012 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10605012 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10605012 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10605012 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10605012 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10605012 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10605012 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10605012 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:10605012 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:10605012 | pubmed:author | pubmed-author:ForniGG | lld:pubmed |
| pubmed-article:10605012 | pubmed:author | pubmed-author:RussoM AMA | lld:pubmed |
| pubmed-article:10605012 | pubmed:author | pubmed-author:CasanovaJ LJL | lld:pubmed |
| pubmed-article:10605012 | pubmed:author | pubmed-author:NovelliFF | lld:pubmed |
| pubmed-article:10605012 | pubmed:author | pubmed-author:GradiniRR | lld:pubmed |
| pubmed-article:10605012 | pubmed:author | pubmed-author:RigamontiLL | lld:pubmed |
| pubmed-article:10605012 | pubmed:author | pubmed-author:JouanguyEE | lld:pubmed |
| pubmed-article:10605012 | pubmed:author | pubmed-author:AriottiSS | lld:pubmed |
| pubmed-article:10605012 | pubmed:author | pubmed-author:LosanaGG | lld:pubmed |
| pubmed-article:10605012 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10605012 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10605012 | pubmed:volume | 164 | lld:pubmed |
| pubmed-article:10605012 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10605012 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10605012 | pubmed:pagination | 201-7 | lld:pubmed |
| pubmed-article:10605012 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:10605012 | pubmed:meshHeading | pubmed-meshheading:10605012... | lld:pubmed |
| pubmed-article:10605012 | pubmed:meshHeading | pubmed-meshheading:10605012... | lld:pubmed |
| pubmed-article:10605012 | pubmed:meshHeading | pubmed-meshheading:10605012... | lld:pubmed |
| pubmed-article:10605012 | pubmed:meshHeading | pubmed-meshheading:10605012... | lld:pubmed |
| pubmed-article:10605012 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10605012 | pubmed:articleTitle | Surface expression of the IFN-gamma R2 chain is regulated by intracellular trafficking in human T lymphocytes. | lld:pubmed |
| pubmed-article:10605012 | pubmed:affiliation | Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy. | lld:pubmed |
| pubmed-article:10605012 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10605012 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10605012 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10605012 | lld:pubmed |
