Cyclophosphamide rescue therapy for chronic rejection after lung transplantation.

Source:http://linkedlifedata.com/resource/pubmed/id/10598739

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General Info

Authors

Demedts M, Delcroix M, Vanhaecke J, Lerut T, Verleden GM, Fabre V, Van Raemdonck D, Buyse B

Affiliation

Department of Respiratory Medicine, University Hospital Gasthuisberg, Leuven, Belgium. geert.verleden@uz.kuleuven.ac.be

Abstract

Obliterative bronchiolitis remains the leading cause of late mortality after heart-lung and lung transplantation. Although several treatment options have been advocated, none has proven to be very successful. Cyclophosphamide is effective in the treatment of idiopathic pulmonary fibrosis, and chronic rejection after lung transplantation is also a fibroproliferative process. We therefore conducted an open, uncontrolled study to look at the effect of cyclophosphamide rescue therapy in the treatment of chronic rejection in lung transplant recipients.

PMID
10598739

Publication types

Clinical Trial; Comparative Study