| pubmed-article:10594921 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10594921 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:10594921 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:10594921 | lifeskim:mentions | umls-concept:C0017639 | lld:lifeskim |
| pubmed-article:10594921 | lifeskim:mentions | umls-concept:C1621967 | lld:lifeskim |
| pubmed-article:10594921 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:10594921 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:10594921 | lifeskim:mentions | umls-concept:C1705938 | lld:lifeskim |
| pubmed-article:10594921 | lifeskim:mentions | umls-concept:C1512571 | lld:lifeskim |
| pubmed-article:10594921 | lifeskim:mentions | umls-concept:C1527178 | lld:lifeskim |
| pubmed-article:10594921 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10594921 | pubmed:dateCreated | 2000-1-18 | lld:pubmed |
| pubmed-article:10594921 | pubmed:abstractText | The electrophysiological properties of Müller cells, the principal glial cells of the retina, are determined by several types of K(+) conductances. Both the absolute and the relative activities of the individual types of K(+) channels undergo important changes in the course of ontogenetic development and during gliosis. Although immature Müller cells express inwardly rectifying K(+) (K(IR)) currents at a very low density, the membrane of normal mature Müller cells is predominated by the K(IR) conductance. The K(IR) channels mediate spatial buffering K(+) currents and maintain a stable hyperpolarized membrane potential necessary for various glial-neuronal interactions. During "conservative" (i.e., non-proliferative) reactive gliosis, the K(IR) conductance of Müller cells is moderately reduced and the cell membrane is slightly depolarized; however, when gliotic Müller cells become proliferative, their K(IR) conductances are dramatically down-regulated; this is accompanied by an increased activity of Ca(2+)-activated K(+) channels and by a conspicuous unstability of their membrane potential. The resultant variations of the membrane potential may increase the activity of depolarization-activated K(+), Na(+) and Ca(2+) channels. It is concluded that in respect to their K(+) current pattern, mature Müller cells pass through a process of dedifferentiation before proliferative activity is initiated. | lld:pubmed |
| pubmed-article:10594921 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10594921 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10594921 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10594921 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10594921 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10594921 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:10594921 | pubmed:issn | 0894-1491 | lld:pubmed |
| pubmed-article:10594921 | pubmed:author | pubmed-author:ReicheltWW | lld:pubmed |
| pubmed-article:10594921 | pubmed:author | pubmed-author:ReichenbachAA | lld:pubmed |
| pubmed-article:10594921 | pubmed:author | pubmed-author:BringmannAA | lld:pubmed |
| pubmed-article:10594921 | pubmed:author | pubmed-author:FaudeFF | lld:pubmed |
| pubmed-article:10594921 | pubmed:author | pubmed-author:BiedermannBB | lld:pubmed |
| pubmed-article:10594921 | pubmed:author | pubmed-author:FranckiAA | lld:pubmed |
| pubmed-article:10594921 | pubmed:author | pubmed-author:PannickeTT | lld:pubmed |
| pubmed-article:10594921 | pubmed:author | pubmed-author:KodajJJ | lld:pubmed |
| pubmed-article:10594921 | pubmed:copyrightInfo | Copyright 2000 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:10594921 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10594921 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10594921 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:10594921 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10594921 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10594921 | pubmed:pagination | 35-44 | lld:pubmed |
| pubmed-article:10594921 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10594921 | pubmed:meshHeading | pubmed-meshheading:10594921... | lld:pubmed |
| pubmed-article:10594921 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10594921 | pubmed:articleTitle | Role of glial K(+) channels in ontogeny and gliosis: a hypothesis based upon studies on Müller cells. | lld:pubmed |
| pubmed-article:10594921 | pubmed:affiliation | Department of Neurophysiology, Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany. bria@server3.medizin.uni-leipzig.de | lld:pubmed |
| pubmed-article:10594921 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10594921 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:10594921 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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