| pubmed-article:1059108 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1059108 | lifeskim:mentions | umls-concept:C0033452 | lld:lifeskim |
| pubmed-article:1059108 | lifeskim:mentions | umls-concept:C0009546 | lld:lifeskim |
| pubmed-article:1059108 | lifeskim:mentions | umls-concept:C1704686 | lld:lifeskim |
| pubmed-article:1059108 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:1059108 | pubmed:dateCreated | 1976-1-16 | lld:pubmed |
| pubmed-article:1059108 | pubmed:abstractText | Activation of the classical complement (C) system involves conversion of C1 to its active state with subsequent cleavage of C4 and -d C2 so as to form the classical C3 convertase, C42 (a bar indicates the activated form of a protein), which sequentially cleaves C3 and C5 to initiate the cytolytic event associated with the complete reaction. An alternative, pr properdin-dependent, pathway to complement activation generates a C3 convertase, C3B, that is formed by cleavage of B with D in the presence of a C3b, the major cleavage fragment of C3. C3b is capable of binding activated properidin (P) with resultant stabilization of C3B, which otherwise rapidly decays by loss of B activity. Initial cleavage of C3, a prerequisite for formation of C3B, is demonstrated to occur through the interaction of native C3 and B in the presence of either D or P alone, or together. The effect of P on the interaction of D, B, and C3 is attributed to stabilization of C3B as has been shown for C3B. Larger amounts of P and B with C3 in the absence of D form a C3 convertase that is designated (P)C3B to indicate that demonstrable cleavage of B does not occur although the active site is available. The generation of this initial convertase, as assessed by C3 inactivation, is dose-related to P and B inputs. The presence of both P and D greatly augments initial cleavage of C3 with D fully uncovering the active site of B and P stabilizing that site. | lld:pubmed |
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| pubmed-article:1059108 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1059108 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1059108 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1059108 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1059108 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:1059108 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:1059108 | pubmed:author | pubmed-author:AustenK FKF | lld:pubmed |
| pubmed-article:1059108 | pubmed:author | pubmed-author:FearonD TDT | lld:pubmed |
| pubmed-article:1059108 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1059108 | pubmed:volume | 72 | lld:pubmed |
| pubmed-article:1059108 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1059108 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1059108 | pubmed:pagination | 3220-4 | lld:pubmed |
| pubmed-article:1059108 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1059108 | pubmed:year | 1975 | lld:pubmed |
| pubmed-article:1059108 | pubmed:articleTitle | Properdin: initiation of alternative complement pathway. | lld:pubmed |
| pubmed-article:1059108 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1059108 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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