| pubmed-article:10585392 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10585392 | lifeskim:mentions | umls-concept:C0162508 | lld:lifeskim |
| pubmed-article:10585392 | lifeskim:mentions | umls-concept:C1367731 | lld:lifeskim |
| pubmed-article:10585392 | lifeskim:mentions | umls-concept:C1150587 | lld:lifeskim |
| pubmed-article:10585392 | lifeskim:mentions | umls-concept:C1705632 | lld:lifeskim |
| pubmed-article:10585392 | lifeskim:mentions | umls-concept:C1428371 | lld:lifeskim |
| pubmed-article:10585392 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:10585392 | lifeskim:mentions | umls-concept:C0332291 | lld:lifeskim |
| pubmed-article:10585392 | pubmed:issue | 50 | lld:pubmed |
| pubmed-article:10585392 | pubmed:dateCreated | 2000-1-13 | lld:pubmed |
| pubmed-article:10585392 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10585392 | pubmed:abstractText | The basic region-leucine zipper transcription factor c-Jun regulates gene expression and cell function. It participates in the formation of homo- or heterodimeric complexes that specifically bind to DNA sequences called activating protein 1 (AP-1) sites. The stability and activity of c-Jun is regulated by phosphorylation within the N-terminal activation domain. Mitogen- and stress-activated c-Jun N-terminal kinases (JNKs) were previously the only described enzymes phosphorylating c-Jun at the N terminus in vivo. In this report we demonstrate a JNK-independent activation of c-Jun in vivo directed by the constitutive photomorphogenesis (COP9) signalosome. The overexpression of signalosome subunit 2 (Sgn2), a subunit of the COP9 signalosome, leads to de novo assembly of the complex with a partial incorporation of the overexpressed subunit. The de novo formation of COP9 signalosome parallels an increase of c-Jun protein resulting in elevated AP-1 transcriptional activity. The c-Jun activation caused by Sgn2 overexpression is independent of JNK and mitogen-activated protein kinase kinase 4. The data demonstrate the existence of a novel COP9 signalosome-directed c-Jun activation pathway. | lld:pubmed |
| pubmed-article:10585392 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10585392 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10585392 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10585392 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:10585392 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:10585392 | pubmed:author | pubmed-author:NaumannMM | lld:pubmed |
| pubmed-article:10585392 | pubmed:author | pubmed-author:HuangXX | lld:pubmed |
| pubmed-article:10585392 | pubmed:author | pubmed-author:DubielWW | lld:pubmed |
| pubmed-article:10585392 | pubmed:author | pubmed-author:FerrellKK | lld:pubmed |
| pubmed-article:10585392 | pubmed:author | pubmed-author:Bech-OtschirD... | lld:pubmed |
| pubmed-article:10585392 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10585392 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:10585392 | pubmed:volume | 274 | lld:pubmed |
| pubmed-article:10585392 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10585392 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10585392 | pubmed:pagination | 35297-300 | lld:pubmed |
| pubmed-article:10585392 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:10585392 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10585392 | pubmed:articleTitle | COP9 signalosome-directed c-Jun activation/stabilization is independent of JNK. | lld:pubmed |
| pubmed-article:10585392 | pubmed:affiliation | Max-Planck-Institut für Infektionsbiologie, Abteilung Molekulare Biologie, Humboldt University, 10117 Berlin, Germany. naumann@mpiib-berlin.mpg.de | lld:pubmed |
| pubmed-article:10585392 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10585392 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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