| pubmed-article:10577927 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10577927 | lifeskim:mentions | umls-concept:C0677886 | lld:lifeskim |
| pubmed-article:10577927 | lifeskim:mentions | umls-concept:C1833334 | lld:lifeskim |
| pubmed-article:10577927 | lifeskim:mentions | umls-concept:C0872180 | lld:lifeskim |
| pubmed-article:10577927 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:10577927 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:10577927 | pubmed:dateCreated | 2000-1-27 | lld:pubmed |
| pubmed-article:10577927 | pubmed:abstractText | We conducted a population-based study to determine the contribution of germline mutations in known candidate genes to ovarian cancer diagnosed at age <30 years. Women with epithelial ovarian cancer were identified through cancer registries. DNA samples were analyzed for mutations in BRCA1, the "ovarian cancer-cluster region" (nucleotides 3139-7069) of BRCA2, and the mismatch-repair genes hMSH2 and hMLH1. Probable germline mutations in hMLH1 were identified in 2 (2%; 95% confidence interval 1%-8%) of 101 women with invasive ovarian cancer diagnosed at age <30 years. No germline mutations were identified in any of the other genes analyzed. There were no striking pedigrees suggestive of families with either breast/ovarian cancer or hereditary nonpolyposis colorectal cancer (HNPCC). There was a significantly increased incidence of all cancers in first-degree relatives of women with invasive disease (relative risk [RR] = 1.6, P=.01) but not in second-degree relatives or in relatives of women with borderline cases. First-degree relatives of women with invasive disease had increased risks of ovarian cancer (RR = 4.8, P=.03), myeloma (RR = 10, P=.01), and non-Hodgkin lymphoma (RR = 7, P=.004). Germline mutations in BRCA1, BRCA2, msh2, and mlh1 contribute to only a minority of cases of early-onset epithelial ovarian cancer. Our data suggest that early-onset ovarian cancer is not associated with a greatly increased risk of cancer in close relatives. | lld:pubmed |
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| pubmed-article:10577927 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10577927 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10577927 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10577927 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10577927 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:10577927 | pubmed:issn | 0002-9297 | lld:pubmed |
| pubmed-article:10577927 | pubmed:author | pubmed-author:ThompsonDD | lld:pubmed |
| pubmed-article:10577927 | pubmed:author | pubmed-author:EvansGG | lld:pubmed |
| pubmed-article:10577927 | pubmed:author | pubmed-author:GoreMM | lld:pubmed |
| pubmed-article:10577927 | pubmed:author | pubmed-author:PonderB ABA | lld:pubmed |
| pubmed-article:10577927 | pubmed:author | pubmed-author:BishopD TDT | lld:pubmed |
| pubmed-article:10577927 | pubmed:author | pubmed-author:ScottII | lld:pubmed |
| pubmed-article:10577927 | pubmed:author | pubmed-author:DalyPP | lld:pubmed |
| pubmed-article:10577927 | pubmed:author | pubmed-author:EastonD FDF | lld:pubmed |
| pubmed-article:10577927 | pubmed:author | pubmed-author:DalalNN | lld:pubmed |
| pubmed-article:10577927 | pubmed:author | pubmed-author:BobrowLL | lld:pubmed |
| pubmed-article:10577927 | pubmed:author | pubmed-author:StrattonJ FJF | lld:pubmed |
| pubmed-article:10577927 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10577927 | pubmed:volume | 65 | lld:pubmed |
| pubmed-article:10577927 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10577927 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10577927 | pubmed:pagination | 1725-32 | lld:pubmed |
| pubmed-article:10577927 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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