Linked Life Data

10567425

Source:http://linkedlifedata.com/resource/pubmed/id/10567425

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:10567425rdf:typepubmed:Citationlld:pubmed
pubmed-article:10567425lifeskim:mentionsumls-concept:C0035569lld:lifeskim
pubmed-article:10567425lifeskim:mentionsumls-concept:C1383501lld:lifeskim
pubmed-article:10567425lifeskim:mentionsumls-concept:C0014239lld:lifeskim
pubmed-article:10567425lifeskim:mentionsumls-concept:C0040715lld:lifeskim
pubmed-article:10567425lifeskim:mentionsumls-concept:C0040549lld:lifeskim
pubmed-article:10567425lifeskim:mentionsumls-concept:C0600688lld:lifeskim
pubmed-article:10567425lifeskim:mentionsumls-concept:C0439857lld:lifeskim
pubmed-article:10567425lifeskim:mentionsumls-concept:C1522702lld:lifeskim
pubmed-article:10567425lifeskim:mentionsumls-concept:C0599718lld:lifeskim
pubmed-article:10567425lifeskim:mentionsumls-concept:C0599813lld:lifeskim
pubmed-article:10567425lifeskim:mentionsumls-concept:C0599893lld:lifeskim
pubmed-article:10567425pubmed:issue48lld:pubmed
pubmed-article:10567425pubmed:dateCreated1999-12-29lld:pubmed
pubmed-article:10567425pubmed:abstractTextRicin acts by translocating to the cytosol the enzymatically active toxin A-chain, which inactivates ribosomes. Retrograde intracellular transport and translocation of ricin was studied under conditions that alter the sensitivity of cells to the toxin. For this purpose tyrosine sulfation of mutant A-chain in the Golgi apparatus, glycosylation in the endoplasmic reticulum (ER) and appearance of A-chain in the cytosolic fraction was monitored. Introduction of an ER retrieval signal, a C-terminal KDEL sequence, into the A-chain increased the toxicity and resulted in more efficient glycosylation, indicating enhanced transport from Golgi to ER. Calcium depletion inhibited neither sulfation nor glycosylation but inhibited translocation and toxicity, suggesting that the toxin is translocated to the cytosol by the pathway used by misfolded proteins that are targeted to the proteasomes for degradation. Slightly acidified medium had a similar effect. The proteasome inhibitor, lactacystin, sensitized cells to ricin and increased the amount of ricin A-chain in the cytosol. Anti-Sec61alpha precipitated sulfated and glycosylated ricin A-chain, suggesting that retrograde toxin translocation involves Sec61p. The data indicate that retrograde translocation across the ER membrane is required for intoxication.lld:pubmed
pubmed-article:10567425pubmed:languageenglld:pubmed
pubmed-article:10567425pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10567425pubmed:citationSubsetIMlld:pubmed
pubmed-article:10567425pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10567425pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10567425pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10567425pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10567425pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10567425pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10567425pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10567425pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10567425pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10567425pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10567425pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10567425pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10567425pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10567425pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10567425pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10567425pubmed:statusMEDLINElld:pubmed
pubmed-article:10567425pubmed:monthNovlld:pubmed
pubmed-article:10567425pubmed:issn0021-9258lld:pubmed
pubmed-article:10567425pubmed:authorpubmed-author:OlsnesSSlld:pubmed
pubmed-article:10567425pubmed:authorpubmed-author:RapakAAlld:pubmed
pubmed-article:10567425pubmed:authorpubmed-author:WescheJJlld:pubmed
pubmed-article:10567425pubmed:issnTypePrintlld:pubmed
pubmed-article:10567425pubmed:day26lld:pubmed
pubmed-article:10567425pubmed:volume274lld:pubmed
pubmed-article:10567425pubmed:ownerNLMlld:pubmed
pubmed-article:10567425pubmed:authorsCompleteYlld:pubmed
pubmed-article:10567425pubmed:pagination34443-9lld:pubmed
pubmed-article:10567425pubmed:dateRevised2006-11-15lld:pubmed
pubmed-article:10567425pubmed:meshHeadingpubmed-meshheading:10567425...lld:pubmed
pubmed-article:10567425pubmed:meshHeadingpubmed-meshheading:10567425...lld:pubmed
pubmed-article:10567425pubmed:meshHeadingpubmed-meshheading:10567425...lld:pubmed
pubmed-article:10567425pubmed:meshHeadingpubmed-meshheading:10567425...lld:pubmed
pubmed-article:10567425pubmed:meshHeadingpubmed-meshheading:10567425...lld:pubmed
pubmed-article:10567425pubmed:meshHeadingpubmed-meshheading:10567425...lld:pubmed
pubmed-article:10567425pubmed:meshHeadingpubmed-meshheading:10567425...lld:pubmed
pubmed-article:10567425pubmed:meshHeadingpubmed-meshheading:10567425...lld:pubmed
pubmed-article:10567425pubmed:meshHeadingpubmed-meshheading:10567425...lld:pubmed
pubmed-article:10567425pubmed:meshHeadingpubmed-meshheading:10567425...lld:pubmed
pubmed-article:10567425pubmed:meshHeadingpubmed-meshheading:10567425...lld:pubmed
pubmed-article:10567425pubmed:meshHeadingpubmed-meshheading:10567425...lld:pubmed
pubmed-article:10567425pubmed:meshHeadingpubmed-meshheading:10567425...lld:pubmed
pubmed-article:10567425pubmed:meshHeadingpubmed-meshheading:10567425...lld:pubmed
pubmed-article:10567425pubmed:meshHeadingpubmed-meshheading:10567425...lld:pubmed
pubmed-article:10567425pubmed:meshHeadingpubmed-meshheading:10567425...lld:pubmed
pubmed-article:10567425pubmed:meshHeadingpubmed-meshheading:10567425...lld:pubmed
pubmed-article:10567425pubmed:meshHeadingpubmed-meshheading:10567425...lld:pubmed
pubmed-article:10567425pubmed:meshHeadingpubmed-meshheading:10567425...lld:pubmed
pubmed-article:10567425pubmed:meshHeadingpubmed-meshheading:10567425...lld:pubmed
pubmed-article:10567425pubmed:meshHeadingpubmed-meshheading:10567425...lld:pubmed
pubmed-article:10567425pubmed:meshHeadingpubmed-meshheading:10567425...lld:pubmed
pubmed-article:10567425pubmed:meshHeadingpubmed-meshheading:10567425...lld:pubmed
pubmed-article:10567425pubmed:meshHeadingpubmed-meshheading:10567425...lld:pubmed
pubmed-article:10567425pubmed:meshHeadingpubmed-meshheading:10567425...lld:pubmed
pubmed-article:10567425pubmed:meshHeadingpubmed-meshheading:10567425...lld:pubmed
pubmed-article:10567425pubmed:meshHeadingpubmed-meshheading:10567425...lld:pubmed
pubmed-article:10567425pubmed:year1999lld:pubmed
pubmed-article:10567425pubmed:articleTitleDependence of ricin toxicity on translocation of the toxin A-chain from the endoplasmic reticulum to the cytosol.lld:pubmed
pubmed-article:10567425pubmed:affiliationInstitute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway.lld:pubmed
pubmed-article:10567425pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10567425pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10567425lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10567425lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10567425lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10567425lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10567425lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10567425lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10567425lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10567425lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10567425lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10567425lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10567425lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10567425lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10567425lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10567425lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10567425lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10567425lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10567425lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10567425lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10567425lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10567425lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10567425lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10567425lld:pubmed
More...