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pubmed-article:10552247pubmed:abstractTextMagnetic resonance imaging (MRI) is frequently used to monitor new treatments in multiple sclerosis (MS), but its role is limited by the uncertain relationship between MRI parameters and clinical disability. A brain MRI study using nine MRI parameters was undertaken in 15 MS patients with a wide spectrum of disability to evaluate the relationship between each parameter and disability. A strong correlation was found between disability (measured using Kurtzke's EDSS) and total lesion load on both proton density (PD; r = 0.79) and T1 (r = 0.71) weighted sequences. There was also a strong correlation of disability with average lesion magnetisation transfer ratio (MTR; r = -0.74) and calculated T1 (r = 0.71) but not with calculated T2 or the average signal intensity of lesions on the conventional T1-weighted, PD-weighted and heavily T2-weighted images. Thus, four parameters which measured either the extent of lesions (PD lesion load) or their pathological severity (MTR, calculated T1, hypointense T1-lesion load) were correlated significantly with disability. While this suggests that such parameters will be useful in treatment trial monitoring, further multi-parameter MRI studies, of larger cohorts and using a wider range of techniques, are indicated.lld:pubmed
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pubmed-article:10552247pubmed:authorpubmed-author:McDonaldW IWIlld:pubmed
pubmed-article:10552247pubmed:authorpubmed-author:ThompsonA JAJlld:pubmed
pubmed-article:10552247pubmed:authorpubmed-author:MillerD HDHlld:pubmed
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pubmed-article:10552247pubmed:authorpubmed-author:MacManusD GDGlld:pubmed
pubmed-article:10552247pubmed:authorpubmed-author:WebbS LSLlld:pubmed
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pubmed-article:10552247pubmed:volume246lld:pubmed
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pubmed-article:10552247pubmed:pagination961-7lld:pubmed
pubmed-article:10552247pubmed:dateRevised2011-11-3lld:pubmed
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pubmed-article:10552247pubmed:year1999lld:pubmed
pubmed-article:10552247pubmed:articleTitleCorrelation of magnetic resonance imaging parameters with clinical disability in multiple sclerosis: a preliminary study.lld:pubmed
pubmed-article:10552247pubmed:affiliationUniversity Department of Clinical Neurology, Institute of Neurology, Queen Square, London WC1N 3BG, UK.lld:pubmed
pubmed-article:10552247pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10552247pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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