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pubmed-article:10549830pubmed:abstractTextThe present study was designed to test the hypothesis that nitric oxide (NO) plays a role in 2-deoxy-D-glucose (2-DG)-induced hypothermia. The body temperature of awake, unrestrained rats was measured before and after the administration of 2-DG, or N(G)-nitro-L-arginine methyl ester (L-NAME; a non-selective NOS inhibitor) or both treatments together. We observed a significant reduction in body temperature after 2-DG injection. L-NAME alone caused no significant change in body temperature. When the two treatments were combined, a reduction in the magnitude of 2-DG-induced hypothermia was observed. The neuronal NOS inhibitor 7-nitroindazole also inhibited 2-DG-induced hypothermia. The data indicate that NO, probably produced by neuronal NOS, plays a role in 2-DG-induced hypothermia.lld:pubmed
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pubmed-article:10549830pubmed:year1999lld:pubmed
pubmed-article:10549830pubmed:articleTitleRole of nitric oxide in 2-deoxy-D-glucose-induced hypothermia in rats.lld:pubmed
pubmed-article:10549830pubmed:affiliationEscola de Enfermagem de Ribeirão Preto, Universidade de São Paulo, SP, Brasil.lld:pubmed
pubmed-article:10549830pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10549830pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed