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pubmed-article:10544295pubmed:abstractTextThe presence and possible role of androgen-metabolizing enzymes in androgen-independent prostate carcinoma (CaP) are still unclear. The aim of the present study was: 1) to evaluate the pattern of androgen metabolism (relative production of 5alpha-reduced vs. 17-keto androgens); and 2) to analyze whether one or both the two known 5alpha-reductase isoforms (5alpha-R1 and 5alpha-R2) and the aromatase (Aro) are expressed and active in this pathology.lld:pubmed
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pubmed-article:10544295pubmed:copyrightInfoCopyright 1999 Wiley-Liss, Inc.lld:pubmed
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pubmed-article:10544295pubmed:articleTitle5alpha-reductase isozymes and aromatase are differentially expressed and active in the androgen-independent human prostate cancer cell lines DU145 and PC3.lld:pubmed
pubmed-article:10544295pubmed:affiliationCenter for Endocrinological Oncology, Department of Endocrinology, University of Milan, Milan, Italy. pnc@mialserver.unimi.itlld:pubmed
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