| pubmed-article:10532280 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10532280 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:10532280 | lifeskim:mentions | umls-concept:C2754943 | lld:lifeskim |
| pubmed-article:10532280 | lifeskim:mentions | umls-concept:C0086140 | lld:lifeskim |
| pubmed-article:10532280 | lifeskim:mentions | umls-concept:C0003261 | lld:lifeskim |
| pubmed-article:10532280 | lifeskim:mentions | umls-concept:C1332709 | lld:lifeskim |
| pubmed-article:10532280 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:10532280 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:10532280 | lifeskim:mentions | umls-concept:C0301625 | lld:lifeskim |
| pubmed-article:10532280 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10532280 | pubmed:dateCreated | 1999-12-7 | lld:pubmed |
| pubmed-article:10532280 | pubmed:abstractText | The humoral immune response against alpha(1-->3) dextran (Dex) in BALB/c mice is characterized by the formation of predominantly IgM antibodies bearing the J558 idiotype. IgG antibodies do not appear in euthymic mice. In athymic animals, however, the response proceeds to a vigorous IgG production. In euthymic mice formation of IgG is suppressed by J558 idiotype specific regulatory T cells recognizing in association with I-Ed and in cognate T/B interaction the V(H) CDR3 derived peptide of the J558 idiotype. Only B-2 lymphocytes produce IgG whereas B-1 cells do not participate in the production of this Ig class. Using novel synthetic all alpha(1-->3)-D-gluco configured tetrasaccharide the Dex-specific B cells can for the first time be analyzed in FACS. In experiments using this newly designed low molecular Dex no signs of B cell apoptosis can be found. This demonstrates a true silencing of persisting Bgamma memory cells as previously suggested by adoptive transfer experiments. In this suppression a further involvement of CD28 and B7-1 interaction can be demonstrated which delivers a necessary costimulatory suppression signal in addition to the cognate TCR/peptide-I-Ed interaction between J558 specific T cells and J558 idiotype bearing B cells. | lld:pubmed |
| pubmed-article:10532280 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10532280 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10532280 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10532280 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10532280 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10532280 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10532280 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10532280 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10532280 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10532280 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10532280 | pubmed:issn | 0171-2985 | lld:pubmed |
| pubmed-article:10532280 | pubmed:author | pubmed-author:KrügerAA | lld:pubmed |
| pubmed-article:10532280 | pubmed:author | pubmed-author:KölschEE | lld:pubmed |
| pubmed-article:10532280 | pubmed:author | pubmed-author:RedlichHH | lld:pubmed |
| pubmed-article:10532280 | pubmed:author | pubmed-author:SpechtCC | lld:pubmed |
| pubmed-article:10532280 | pubmed:author | pubmed-author:RademaekersAA | lld:pubmed |
| pubmed-article:10532280 | pubmed:author | pubmed-author:JunkerRR | lld:pubmed |
| pubmed-article:10532280 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10532280 | pubmed:volume | 201 | lld:pubmed |
| pubmed-article:10532280 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10532280 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10532280 | pubmed:pagination | 49-63 | lld:pubmed |
| pubmed-article:10532280 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:10532280 | pubmed:meshHeading | pubmed-meshheading:10532280... | lld:pubmed |
| pubmed-article:10532280 | pubmed:meshHeading | pubmed-meshheading:10532280... | lld:pubmed |
| pubmed-article:10532280 | pubmed:meshHeading | pubmed-meshheading:10532280... | lld:pubmed |
| pubmed-article:10532280 | pubmed:meshHeading | pubmed-meshheading:10532280... | lld:pubmed |
| pubmed-article:10532280 | pubmed:meshHeading | pubmed-meshheading:10532280... | lld:pubmed |
| pubmed-article:10532280 | pubmed:meshHeading | pubmed-meshheading:10532280... | lld:pubmed |
| pubmed-article:10532280 | pubmed:meshHeading | pubmed-meshheading:10532280... | lld:pubmed |
| pubmed-article:10532280 | pubmed:meshHeading | pubmed-meshheading:10532280... | lld:pubmed |
| pubmed-article:10532280 | pubmed:meshHeading | pubmed-meshheading:10532280... | lld:pubmed |
| pubmed-article:10532280 | pubmed:meshHeading | pubmed-meshheading:10532280... | lld:pubmed |
| pubmed-article:10532280 | pubmed:meshHeading | pubmed-meshheading:10532280... | lld:pubmed |
| pubmed-article:10532280 | pubmed:meshHeading | pubmed-meshheading:10532280... | lld:pubmed |
| pubmed-article:10532280 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10532280 | pubmed:articleTitle | Involvement of CD28 cosignalling in the T cell-mediated suppression of the IgG antibody response against the TI-2 antigen alpha(1-->3) dextran. | lld:pubmed |
| pubmed-article:10532280 | pubmed:affiliation | Institute for Immunology, University of Münster, Germany. specht@uni-muenster.de | lld:pubmed |
| pubmed-article:10532280 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10532280 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10532280 | lld:pubmed |
