| pubmed-article:10520725 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10520725 | lifeskim:mentions | umls-concept:C0003402 | lld:lifeskim |
| pubmed-article:10520725 | lifeskim:mentions | umls-concept:C0282774 | lld:lifeskim |
| pubmed-article:10520725 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:10520725 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:10520725 | pubmed:dateCreated | 1999-11-10 | lld:pubmed |
| pubmed-article:10520725 | pubmed:abstractText | It is well known that aminoguanidine (AG) can diminish advanced glycosylation of proteins, which might be beneficial in preventing chronic diabetic complications. Recent reports suggested an inter-relationship between glycosylation of protein and free radical damage. In the present study, we examined the free radical scavenging properties of AG. Electron paramagnetic resonance using the spin-trap 5,5-dimethyl-1-pyrroline N-oxide (DMPO) was performed to determine the superoxide and hydroxyl radical scavenging abilities of AG. These experiments revealed that AG was an effective hydroxyl radical scavenger even though it expressed a direct inhibitory effect on the xanthine oxidase activity at high concentrations (AG > or = 5 mM). In the second part of the study, allophycocyanin was used as an indicator of free radical mediated protein damage. In the assay, 2,2'-azobis(2-amidinopropane) hydrochloride (AAPH) was used as a peroxyl radical generator, and the loss of allophycocyanin fluorescence was monitored. The antioxidant effect of AG was expressed in oxygen-radical absorbing capacity (ORAC), where one ORAC unit equals the net protection produced by 1 microM Trolox (a water soluble analogue of vitamin E) as a control standard. AG exhibited a significant dose-dependent effect against free radical damage. These radical scavenging properties of AG may contribute to protective effects during glycation and explain the prevention of diabetic complications. | lld:pubmed |
| pubmed-article:10520725 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10520725 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10520725 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10520725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10520725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10520725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10520725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10520725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10520725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10520725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10520725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10520725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10520725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10520725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10520725 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10520725 | pubmed:issn | 0767-3981 | lld:pubmed |
| pubmed-article:10520725 | pubmed:author | pubmed-author:RochetteLL | lld:pubmed |
| pubmed-article:10520725 | pubmed:author | pubmed-author:MaupoilVV | lld:pubmed |
| pubmed-article:10520725 | pubmed:author | pubmed-author:DallozFF | lld:pubmed |
| pubmed-article:10520725 | pubmed:author | pubmed-author:Courderot-Mas... | lld:pubmed |
| pubmed-article:10520725 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10520725 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:10520725 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10520725 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10520725 | pubmed:pagination | 535-40 | lld:pubmed |
| pubmed-article:10520725 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:10520725 | pubmed:meshHeading | pubmed-meshheading:10520725... | lld:pubmed |
| pubmed-article:10520725 | pubmed:meshHeading | pubmed-meshheading:10520725... | lld:pubmed |
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| pubmed-article:10520725 | pubmed:meshHeading | pubmed-meshheading:10520725... | lld:pubmed |
| pubmed-article:10520725 | pubmed:meshHeading | pubmed-meshheading:10520725... | lld:pubmed |
| pubmed-article:10520725 | pubmed:meshHeading | pubmed-meshheading:10520725... | lld:pubmed |
| pubmed-article:10520725 | pubmed:meshHeading | pubmed-meshheading:10520725... | lld:pubmed |
| pubmed-article:10520725 | pubmed:meshHeading | pubmed-meshheading:10520725... | lld:pubmed |
| pubmed-article:10520725 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10520725 | pubmed:articleTitle | Antioxidant properties of aminoguanidine. | lld:pubmed |
| pubmed-article:10520725 | pubmed:affiliation | LPPCE, Facultés de Médecine et Pharmacie, Dijon, France. | lld:pubmed |
| pubmed-article:10520725 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10520725 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10520725 | lld:pubmed |
