| pubmed-article:10519498 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10519498 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10519498 | lifeskim:mentions | umls-concept:C0014563 | lld:lifeskim |
| pubmed-article:10519498 | lifeskim:mentions | umls-concept:C0023660 | lld:lifeskim |
| pubmed-article:10519498 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:10519498 | lifeskim:mentions | umls-concept:C0449297 | lld:lifeskim |
| pubmed-article:10519498 | lifeskim:mentions | umls-concept:C0206056 | lld:lifeskim |
| pubmed-article:10519498 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:10519498 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:10519498 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:10519498 | pubmed:dateCreated | 1999-10-27 | lld:pubmed |
| pubmed-article:10519498 | pubmed:abstractText | Local anesthetic nerve block prolonged by epinephrine is thought to result from local vasoconstriction and consequent decreased local anesthetic clearance from the injection site. However, no study has yet confirmed this directly in humans by measuring tissue concentrations of local anesthetic over time. In addition, recent studies have shown that the alpha2-adrenergic receptor agonist, clonidine, also prolongs nerve block without altering local anesthetic clearance. Because epinephrine is also an alpha2-adrenergic receptor agonist, it is possible that epinephrine prolongs local anesthetic block by a pharmacodynamic mechanism and not a pharmacokinetic one. This study was designed to address this issue. | lld:pubmed |
| pubmed-article:10519498 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10519498 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10519498 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10519498 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:10519498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10519498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10519498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10519498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10519498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10519498 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10519498 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:10519498 | pubmed:issn | 0003-3022 | lld:pubmed |
| pubmed-article:10519498 | pubmed:author | pubmed-author:BernardsC MCM | lld:pubmed |
| pubmed-article:10519498 | pubmed:author | pubmed-author:KopaczD JDJ | lld:pubmed |
| pubmed-article:10519498 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10519498 | pubmed:volume | 91 | lld:pubmed |
| pubmed-article:10519498 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10519498 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10519498 | pubmed:pagination | 962-8 | lld:pubmed |
| pubmed-article:10519498 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:10519498 | pubmed:meshHeading | pubmed-meshheading:10519498... | lld:pubmed |
| pubmed-article:10519498 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10519498 | pubmed:articleTitle | Effect of epinephrine on lidocaine clearance in vivo: a microdialysis study in humans. | lld:pubmed |
| pubmed-article:10519498 | pubmed:affiliation | Department of Anesthesiology, University of Washington, Seattle 98195, USA. chrisb@u.washington.edu | lld:pubmed |
| pubmed-article:10519498 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10519498 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:10519498 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10519498 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
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