| pubmed-article:10516074 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:10516074 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10516074 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:10516074 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:10516074 | lifeskim:mentions | umls-concept:C0445223 | lld:lifeskim |
| pubmed-article:10516074 | lifeskim:mentions | umls-concept:C1552599 | lld:lifeskim |
| pubmed-article:10516074 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:10516074 | lifeskim:mentions | umls-concept:C1704787 | lld:lifeskim |
| pubmed-article:10516074 | lifeskim:mentions | umls-concept:C0318599 | lld:lifeskim |
| pubmed-article:10516074 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:10516074 | pubmed:dateCreated | 1999-11-4 | lld:pubmed |
| pubmed-article:10516074 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10516074 | pubmed:abstractText | Porcine enteric calicivirus (PEC) is associated with diarrhea in pigs, and to date it is the only cultivable enteric calicivirus (tissue culture-adapted [TC] PEC/Cowden). Based on sequence analysis of cDNA clones and reverse transcription-PCR products, TC PEC/Cowden has an RNA genome of 7,320 bp, excluding its 3' poly(A)(+) tail. The genome is organized in two open reading frames (ORFs), similar to the organizations of the human Sapporo-like viruses (SLVs) and the lagoviruses. ORF1 encodes the polyprotein that is fused to and contiguous with the capsid protein. ORF2 at the 3' end encodes a small basic protein of 164 amino acids. Among caliciviruses, PEC has the highest amino acid sequence identities in the putative RNA polymerase (66%), 2C helicase (49.6%), 3C-like protease (43.7%), and capsid (39%) regions with the SLVs, indicating that PEC is genetically most closely related to the SLVs. The complete RNA genome of wild-type (WT) PEC/Cowden was also sequenced. Sequence comparisons revealed that the WT and TC PEC/Cowden have 100% nucleotide sequence identities in the 5' terminus, 2C helicase, ORF2, and the 3' nontranslated region. TC PEC/Cowden has one silent mutation in its protease, two amino acid changes and a silent mutation in its RNA polymerase, and five nucleotide substitutions in its capsid that result in one distant and three clustered amino acid changes and a silent mutation. These substitutions may be associated with adaptation of TC PEC/Cowden to cell culture. The cultivable PEC should be a useful model for studies of the pathogenesis, replication, and possible rescue of uncultivable human enteric caliciviruses. | lld:pubmed |
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| pubmed-article:10516074 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10516074 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10516074 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10516074 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10516074 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10516074 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:10516074 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:10516074 | pubmed:author | pubmed-author:YUH HHH | lld:pubmed |
| pubmed-article:10516074 | pubmed:author | pubmed-author:HardyM EME | lld:pubmed |
| pubmed-article:10516074 | pubmed:author | pubmed-author:SaifL JLJ | lld:pubmed |
| pubmed-article:10516074 | pubmed:author | pubmed-author:ZhangQQ | lld:pubmed |
| pubmed-article:10516074 | pubmed:author | pubmed-author:ParwaniA VAV | lld:pubmed |
| pubmed-article:10516074 | pubmed:author | pubmed-author:ChangK OKO | lld:pubmed |
| pubmed-article:10516074 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10516074 | pubmed:volume | 73 | lld:pubmed |
| pubmed-article:10516074 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10516074 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10516074 | pubmed:pagination | 9625-31 | lld:pubmed |
| pubmed-article:10516074 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:10516074 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10516074 | pubmed:articleTitle | Molecular characterization of a porcine enteric calicivirus genetically related to Sapporo-like human caliciviruses. | lld:pubmed |
| pubmed-article:10516074 | pubmed:affiliation | Food Animal Health Research Program, Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio 44691, USA. | lld:pubmed |
| pubmed-article:10516074 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10516074 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:10516074 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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