| pubmed-article:10512748 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10512748 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10512748 | lifeskim:mentions | umls-concept:C0029246 | lld:lifeskim |
| pubmed-article:10512748 | lifeskim:mentions | umls-concept:C0026682 | lld:lifeskim |
| pubmed-article:10512748 | lifeskim:mentions | umls-concept:C0017428 | lld:lifeskim |
| pubmed-article:10512748 | lifeskim:mentions | umls-concept:C1749467 | lld:lifeskim |
| pubmed-article:10512748 | lifeskim:mentions | umls-concept:C0002345 | lld:lifeskim |
| pubmed-article:10512748 | lifeskim:mentions | umls-concept:C1417495 | lld:lifeskim |
| pubmed-article:10512748 | lifeskim:mentions | umls-concept:C1883633 | lld:lifeskim |
| pubmed-article:10512748 | lifeskim:mentions | umls-concept:C0681842 | lld:lifeskim |
| pubmed-article:10512748 | lifeskim:mentions | umls-concept:C0376315 | lld:lifeskim |
| pubmed-article:10512748 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:10512748 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10512748 | pubmed:dateCreated | 1999-11-23 | lld:pubmed |
| pubmed-article:10512748 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10512748 | pubmed:abstractText | The MUC3 gene encodes a large, glycosylated mucin produced by intestinal epithelial cells to form a protective barrier against the external environment. Recently published cDNA sequences for the carboxyl-terminal region of MUC3 polypeptide indicated that rodent Muc3 possesses two epidermal growth factor (EGF)-like domains, and putative transmembrane and cytoplasmic domains, whereas the sequence of human MUC3 predicted termination after the first EGF-like domain. Here we describe the complete genomic sequence encompassing the carboxyl terminal region of human MUC3, revealing the boundaries of 11 exons. RT-PCR and cDNA library cloning experiments indicate that the gene is alternatively spliced, yielding a major membrane-bound form as well as multiple soluble forms. Thus, this work indicates that both membrane-bound and soluble MUC3 mucin proteins are produced by alternative splicing of a single gene. A potentially important polymorphism involving a Tyr residue with a proposed role in signalling is described as well. | lld:pubmed |
| pubmed-article:10512748 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10512748 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10512748 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10512748 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10512748 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10512748 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10512748 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10512748 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10512748 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10512748 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10512748 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10512748 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:10512748 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:10512748 | pubmed:author | pubmed-author:AubertJ PJP | lld:pubmed |
| pubmed-article:10512748 | pubmed:author | pubmed-author:KimY SYS | lld:pubmed |
| pubmed-article:10512748 | pubmed:author | pubmed-author:SwallowD MDM | lld:pubmed |
| pubmed-article:10512748 | pubmed:author | pubmed-author:NgRR | lld:pubmed |
| pubmed-article:10512748 | pubmed:author | pubmed-author:HicksJ WJW | lld:pubmed |
| pubmed-article:10512748 | pubmed:author | pubmed-author:CrawleyS CSC | lld:pubmed |
| pubmed-article:10512748 | pubmed:author | pubmed-author:PrattW SWS | lld:pubmed |
| pubmed-article:10512748 | pubmed:copyrightInfo | Copyright 1999 Academic Press. | lld:pubmed |
| pubmed-article:10512748 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10512748 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:10512748 | pubmed:volume | 263 | lld:pubmed |
| pubmed-article:10512748 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10512748 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10512748 | pubmed:pagination | 728-36 | lld:pubmed |
| pubmed-article:10512748 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:10512748 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10512748 | pubmed:articleTitle | Genomic organization and structure of the 3' region of human MUC3: alternative splicing predicts membrane-bound and soluble forms of the mucin. | lld:pubmed |
| pubmed-article:10512748 | pubmed:affiliation | Department of Medicine, University of California, San Francisco, California 94143, USA. | lld:pubmed |
| pubmed-article:10512748 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10512748 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10512748 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:10512748 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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