| pubmed-article:10500199 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10500199 | lifeskim:mentions | umls-concept:C0023418 | lld:lifeskim |
| pubmed-article:10500199 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:10500199 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:10500199 | lifeskim:mentions | umls-concept:C0205178 | lld:lifeskim |
| pubmed-article:10500199 | lifeskim:mentions | umls-concept:C0598306 | lld:lifeskim |
| pubmed-article:10500199 | lifeskim:mentions | umls-concept:C1515877 | lld:lifeskim |
| pubmed-article:10500199 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:10500199 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:10500199 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:10500199 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:10500199 | pubmed:dateCreated | 1999-10-21 | lld:pubmed |
| pubmed-article:10500199 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:abstractText | A large fraction of pediatric pre-B acute lymphoblastoid leukemias (ALL) consistently contain a t(1;19) chromosomal translocation. The t(1;19) translocation results in the production of a chimeric transcription factor containing the N-terminal transactivation domain of E2A fused to the C-terminal DNA-binding homeodomain of Pbx1. Here, we show that the E2A-Pbx1 fusion protein activates the expression of a novel WNT gene, WNT-16. WNT-16 normally is expressed in peripheral lymphoid organs such as spleen, appendix, and lymph nodes, but not in bone marrow. In contrast, high levels of WNT-16 transcripts are present in bone marrow and cell lines derived from pre-B ALL patients carrying the E2A-Pbx1 hybrid gene. Inhibition of E2A-Pbx1 expression leads to a significant decrease in WNT-16 mRNA levels, suggesting that WNT-16 is a downstream target of E2A-Pbx1. Three putative WNT receptors, FZ-2, FZ-3, and FZ-5, are expressed in cells of the B lineage, including pre-B ALL cells aberrantly expressing WNT-16. We propose that a WNT-16-mediated autocrine growth mechanism contributes to the development of t(1;19) pre-B ALL. | lld:pubmed |
| pubmed-article:10500199 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10500199 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10500199 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500199 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10500199 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10500199 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:10500199 | pubmed:author | pubmed-author:DowningJ RJR | lld:pubmed |
| pubmed-article:10500199 | pubmed:author | pubmed-author:MoniaB PBP | lld:pubmed |
| pubmed-article:10500199 | pubmed:author | pubmed-author:MurreCC | lld:pubmed |
| pubmed-article:10500199 | pubmed:author | pubmed-author:McWhirterJ... | lld:pubmed |
| pubmed-article:10500199 | pubmed:author | pubmed-author:WancewiczE... | lld:pubmed |
| pubmed-article:10500199 | pubmed:author | pubmed-author:NeuteboomS... | lld:pubmed |
| pubmed-article:10500199 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10500199 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:10500199 | pubmed:volume | 96 | lld:pubmed |
| pubmed-article:10500199 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10500199 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10500199 | pubmed:pagination | 11464-9 | lld:pubmed |
| pubmed-article:10500199 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:10500199 | pubmed:meshHeading | pubmed-meshheading:10500199... | lld:pubmed |
| pubmed-article:10500199 | pubmed:meshHeading | pubmed-meshheading:10500199... | lld:pubmed |
| pubmed-article:10500199 | pubmed:meshHeading | pubmed-meshheading:10500199... | lld:pubmed |
| pubmed-article:10500199 | pubmed:meshHeading | pubmed-meshheading:10500199... | lld:pubmed |
| pubmed-article:10500199 | pubmed:meshHeading | pubmed-meshheading:10500199... | lld:pubmed |
| pubmed-article:10500199 | pubmed:meshHeading | pubmed-meshheading:10500199... | lld:pubmed |
| pubmed-article:10500199 | pubmed:meshHeading | pubmed-meshheading:10500199... | lld:pubmed |
| pubmed-article:10500199 | pubmed:meshHeading | pubmed-meshheading:10500199... | lld:pubmed |
| pubmed-article:10500199 | pubmed:meshHeading | pubmed-meshheading:10500199... | lld:pubmed |
| pubmed-article:10500199 | pubmed:meshHeading | pubmed-meshheading:10500199... | lld:pubmed |
| pubmed-article:10500199 | pubmed:meshHeading | pubmed-meshheading:10500199... | lld:pubmed |
| pubmed-article:10500199 | pubmed:meshHeading | pubmed-meshheading:10500199... | lld:pubmed |
