| pubmed-article:10471742 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10471742 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:10471742 | lifeskim:mentions | umls-concept:C0024660 | lld:lifeskim |
| pubmed-article:10471742 | lifeskim:mentions | umls-concept:C1179435 | lld:lifeskim |
| pubmed-article:10471742 | lifeskim:mentions | umls-concept:C0035678 | lld:lifeskim |
| pubmed-article:10471742 | lifeskim:mentions | umls-concept:C0012899 | lld:lifeskim |
| pubmed-article:10471742 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:10471742 | lifeskim:mentions | umls-concept:C0332256 | lld:lifeskim |
| pubmed-article:10471742 | lifeskim:mentions | umls-concept:C1705248 | lld:lifeskim |
| pubmed-article:10471742 | lifeskim:mentions | umls-concept:C1548799 | lld:lifeskim |
| pubmed-article:10471742 | lifeskim:mentions | umls-concept:C1524073 | lld:lifeskim |
| pubmed-article:10471742 | lifeskim:mentions | umls-concept:C0449432 | lld:lifeskim |
| pubmed-article:10471742 | pubmed:issue | 18 | lld:pubmed |
| pubmed-article:10471742 | pubmed:dateCreated | 1999-11-4 | lld:pubmed |
| pubmed-article:10471742 | pubmed:abstractText | Traditional models for transcription initiation by RNA polymerase I include a stepwise assembly of basic transcription factors/regulatory proteins on the core promoter to form a preinitiation complex. In contrast, we have identified a preassembled RNA polymerase I (RPI) complex that contains all the factors necessary and sufficient to initiate transcription from the rDNA promoter in vitro. The purified RPI holoenzyme contains the RPI homolog of TFIID, SL-1 and the rDNA transcription terminator factor (TTF-1), but lacks UBF, an activator of rDNA transcription. Certain components of the DNA repair/replication system, including Ku70/80, DNA topoisomerase I and PCNA, are also associated with the RPI complex. We have found that the holo-enzyme supported specific transcription and that specific transcription was stimulated by the RPI transcription activator UBF. These results support the hypothesis that a fraction of the RPI exists as a preassembled, transcriptionally competent complex that is readily recruited to the rDNA promoter, i.e. as a holoenzyme, and provide important new insights into the mechanisms governing initiation by RPI. | lld:pubmed |
| pubmed-article:10471742 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10471742 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10471742 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10471742 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10471742 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10471742 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10471742 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10471742 | pubmed:issn | 1362-4962 | lld:pubmed |
| pubmed-article:10471742 | pubmed:author | pubmed-author:MossTT | lld:pubmed |
| pubmed-article:10471742 | pubmed:author | pubmed-author:CavanaughAA | lld:pubmed |
| pubmed-article:10471742 | pubmed:author | pubmed-author:HempelW MWM | lld:pubmed |
| pubmed-article:10471742 | pubmed:author | pubmed-author:HannanR DRD | lld:pubmed |
| pubmed-article:10471742 | pubmed:author | pubmed-author:RothblumLL | lld:pubmed |
| pubmed-article:10471742 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:10471742 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:10471742 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:10471742 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10471742 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10471742 | pubmed:pagination | 3720-7 | lld:pubmed |
| pubmed-article:10471742 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:10471742 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10471742 | pubmed:articleTitle | Identification of a mammalian RNA polymerase I holoenzyme containing components of the DNA repair/replication system. | lld:pubmed |
| pubmed-article:10471742 | pubmed:affiliation | Cancer Research Centre and Department of Biochemistry, Laval University, Hotel-Dieu de Quebec, 11 Cote du Palais, Quebec G1R 2J6, Canada. | lld:pubmed |
| pubmed-article:10471742 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10471742 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10471742 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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