Linked Life Data

10465426

Source:http://linkedlifedata.com/resource/pubmed/id/10465426

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:10465426rdf:typepubmed:Citationlld:pubmed
pubmed-article:10465426lifeskim:mentionsumls-concept:C0086418lld:lifeskim
pubmed-article:10465426lifeskim:mentionsumls-concept:C0162783lld:lifeskim
pubmed-article:10465426lifeskim:mentionsumls-concept:C0036341lld:lifeskim
pubmed-article:10465426lifeskim:mentionsumls-concept:C0035696lld:lifeskim
pubmed-article:10465426lifeskim:mentionsumls-concept:C0016904lld:lifeskim
pubmed-article:10465426lifeskim:mentionsumls-concept:C0034807lld:lifeskim
pubmed-article:10465426lifeskim:mentionsumls-concept:C0242485lld:lifeskim
pubmed-article:10465426lifeskim:mentionsumls-concept:C1979844lld:lifeskim
pubmed-article:10465426lifeskim:mentionsumls-concept:C0040649lld:lifeskim
pubmed-article:10465426lifeskim:mentionsumls-concept:C0205234lld:lifeskim
pubmed-article:10465426lifeskim:mentionsumls-concept:C0549193lld:lifeskim
pubmed-article:10465426lifeskim:mentionsumls-concept:C1550605lld:lifeskim
pubmed-article:10465426lifeskim:mentionsumls-concept:C1711351lld:lifeskim
pubmed-article:10465426lifeskim:mentionsumls-concept:C0456205lld:lifeskim
pubmed-article:10465426pubmed:issue2lld:pubmed
pubmed-article:10465426pubmed:dateCreated1999-10-7lld:pubmed
pubmed-article:10465426pubmed:abstractTextThe hypothesis that the pathophysiology of schizophrenia may be associated with a dysfunction in GABA transmission in the human prefrontal cortex was investigated. Human post mortem brain tissue from 10 control cases and six cases of schizophrenia were processed for amino acid analysis and for radioactive in situ hybridization. Laminae III and V of three prefrontal cortical areas were examined in detail, namely Brodmann areas 9, 10 and 11. Of these three areas significant changes in GABAergic markers were found only in areas 9 and 10. Of note, a significant decrease in the tissue content of GABA was observed and this was accompanied by a marked increase in the cellular expression of the GABA(A) receptor alpha-1 subunit messenger RNA and a marked decrease in the expression of human GABA transporter-1, the messenger RNA encoding the neuronal GABA transporter protein. The amino acid analysis data provided in this study coupled with the detailed cellular study of several GABAergic markers in the human prefrontal cortex provide direct evidence in support of a disturbance in GABA transmission in the prefrontal cortex, which may be loosely termed "hypofrontality".lld:pubmed
pubmed-article:10465426pubmed:languageenglld:pubmed
pubmed-article:10465426pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10465426pubmed:citationSubsetIMlld:pubmed
pubmed-article:10465426pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10465426pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10465426pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10465426pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10465426pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10465426pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10465426pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10465426pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10465426pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10465426pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10465426pubmed:statusMEDLINElld:pubmed
pubmed-article:10465426pubmed:issn0306-4522lld:pubmed
pubmed-article:10465426pubmed:authorpubmed-author:EmsonP CPClld:pubmed
pubmed-article:10465426pubmed:authorpubmed-author:AraiHHlld:pubmed
pubmed-article:10465426pubmed:authorpubmed-author:McKennaP JPJlld:pubmed
pubmed-article:10465426pubmed:authorpubmed-author:OhnumaTTlld:pubmed
pubmed-article:10465426pubmed:authorpubmed-author:AugoodS JSJlld:pubmed
pubmed-article:10465426pubmed:issnTypePrintlld:pubmed
pubmed-article:10465426pubmed:volume93lld:pubmed
pubmed-article:10465426pubmed:ownerNLMlld:pubmed
pubmed-article:10465426pubmed:authorsCompleteYlld:pubmed
pubmed-article:10465426pubmed:pagination441-8lld:pubmed
pubmed-article:10465426pubmed:dateRevised2006-11-20lld:pubmed
pubmed-article:10465426pubmed:meshHeadingpubmed-meshheading:10465426...lld:pubmed
pubmed-article:10465426pubmed:meshHeadingpubmed-meshheading:10465426...lld:pubmed
pubmed-article:10465426pubmed:meshHeadingpubmed-meshheading:10465426...lld:pubmed
pubmed-article:10465426pubmed:meshHeadingpubmed-meshheading:10465426...lld:pubmed
pubmed-article:10465426pubmed:meshHeadingpubmed-meshheading:10465426...lld:pubmed
pubmed-article:10465426pubmed:meshHeadingpubmed-meshheading:10465426...lld:pubmed
pubmed-article:10465426pubmed:meshHeadingpubmed-meshheading:10465426...lld:pubmed
pubmed-article:10465426pubmed:meshHeadingpubmed-meshheading:10465426...lld:pubmed
pubmed-article:10465426pubmed:meshHeadingpubmed-meshheading:10465426...lld:pubmed
pubmed-article:10465426pubmed:meshHeadingpubmed-meshheading:10465426...lld:pubmed
pubmed-article:10465426pubmed:meshHeadingpubmed-meshheading:10465426...lld:pubmed
pubmed-article:10465426pubmed:meshHeadingpubmed-meshheading:10465426...lld:pubmed
pubmed-article:10465426pubmed:meshHeadingpubmed-meshheading:10465426...lld:pubmed
pubmed-article:10465426pubmed:meshHeadingpubmed-meshheading:10465426...lld:pubmed
pubmed-article:10465426pubmed:meshHeadingpubmed-meshheading:10465426...lld:pubmed
pubmed-article:10465426pubmed:meshHeadingpubmed-meshheading:10465426...lld:pubmed
pubmed-article:10465426pubmed:meshHeadingpubmed-meshheading:10465426...lld:pubmed
pubmed-article:10465426pubmed:meshHeadingpubmed-meshheading:10465426...lld:pubmed
pubmed-article:10465426pubmed:meshHeadingpubmed-meshheading:10465426...lld:pubmed
pubmed-article:10465426pubmed:year1999lld:pubmed
pubmed-article:10465426pubmed:articleTitleMeasurement of GABAergic parameters in the prefrontal cortex in schizophrenia: focus on GABA content, GABA(A) receptor alpha-1 subunit messenger RNA and human GABA transporter-1 (HGAT-1) messenger RNA expression.lld:pubmed
pubmed-article:10465426pubmed:affiliationDepartment of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan.lld:pubmed
pubmed-article:10465426pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10465426pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10465426lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10465426lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10465426lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10465426lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10465426lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10465426lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10465426lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10465426lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10465426lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10465426lld:pubmed