| pubmed-article:10452990 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10452990 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:10452990 | lifeskim:mentions | umls-concept:C0021758 | lld:lifeskim |
| pubmed-article:10452990 | lifeskim:mentions | umls-concept:C0085295 | lld:lifeskim |
| pubmed-article:10452990 | lifeskim:mentions | umls-concept:C1335877 | lld:lifeskim |
| pubmed-article:10452990 | lifeskim:mentions | umls-concept:C0024880 | lld:lifeskim |
| pubmed-article:10452990 | lifeskim:mentions | umls-concept:C0031621 | lld:lifeskim |
| pubmed-article:10452990 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:10452990 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10452990 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:10452990 | lifeskim:mentions | umls-concept:C1690540 | lld:lifeskim |
| pubmed-article:10452990 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:10452990 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:10452990 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:10452990 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:10452990 | pubmed:dateCreated | 1999-9-14 | lld:pubmed |
| pubmed-article:10452990 | pubmed:abstractText | The c-kit protooncogene encodes a receptor tyrosine kinase that is known to play a critical role in hemopoiesis and is essential for mast cell growth, differentiation, and cytokine production. Studies have shown that the Th2 cytokine IL-4 can down-regulate Kit expression on human and murine mast cells, but the mechanism of this down-regulation has remained unresolved. Using mouse bone marrow-derived mast cells, we demonstrate that IL-4-mediated Kit down-regulation requires STAT6 expression and phosphotidylinositide-3'-kinase activation. We also find that the Th2 cytokine IL-10 potently down-regulates Kit expression. IL-4 enhances IL-10-mediated inhibition in a manner that is STAT6 independent and phosphotidylinositide-3'-kinase dependent. Both IL-4- and IL-10-mediated Kit down-regulation were coupled with little or no change in c-kit mRNA levels, no significant change in Kit protein stability, but decreased total Kit protein expression. Inhibition of Kit expression by IL-4 and IL-10 resulted in a loss of Kit-mediated signaling, as evidenced by reduced IL-13 and TNF-alpha mRNA induction after stem cell factor stimulation. These data offer a role for STAT6 and phosphotidylinositide-3'-kinase in IL-4-mediated Kit down-regulation, coupled with the novel observation that IL-10 is a potent inhibitor of Kit expression and function. Regulating Kit expression and signaling may be essential to controlling mast cell-mediated inflammatory responses. | lld:pubmed |
| pubmed-article:10452990 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10452990 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10452990 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10452990 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:10452990 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10452990 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10452990 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:10452990 | pubmed:author | pubmed-author:RyanJ JJJ | lld:pubmed |
| pubmed-article:10452990 | pubmed:author | pubmed-author:ShelburneC... | lld:pubmed |
| pubmed-article:10452990 | pubmed:author | pubmed-author:MirmonsefPP | lld:pubmed |
| pubmed-article:10452990 | pubmed:author | pubmed-author:Fitzhugh... | lld:pubmed |
| pubmed-article:10452990 | pubmed:author | pubmed-author:ChongH JHJ | lld:pubmed |
| pubmed-article:10452990 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10452990 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10452990 | pubmed:volume | 163 | lld:pubmed |
| pubmed-article:10452990 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10452990 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10452990 | pubmed:pagination | 2530-9 | lld:pubmed |
| pubmed-article:10452990 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:10452990 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10452990 | pubmed:articleTitle | Inhibition of Kit expression by IL-4 and IL-10 in murine mast cells: role of STAT6 and phosphatidylinositol 3'-kinase. | lld:pubmed |
| pubmed-article:10452990 | pubmed:affiliation | Department of Biology, Virginia Commonwealth University, Richmond 23284, USA. | lld:pubmed |
| pubmed-article:10452990 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10452990 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10452990 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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