| pubmed-article:10430908 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10430908 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:10430908 | lifeskim:mentions | umls-concept:C0288331 | lld:lifeskim |
| pubmed-article:10430908 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:10430908 | lifeskim:mentions | umls-concept:C0038952 | lld:lifeskim |
| pubmed-article:10430908 | lifeskim:mentions | umls-concept:C0041904 | lld:lifeskim |
| pubmed-article:10430908 | lifeskim:mentions | umls-concept:C1539081 | lld:lifeskim |
| pubmed-article:10430908 | lifeskim:mentions | umls-concept:C0162493 | lld:lifeskim |
| pubmed-article:10430908 | lifeskim:mentions | umls-concept:C1332397 | lld:lifeskim |
| pubmed-article:10430908 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:10430908 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:10430908 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:10430908 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:10430908 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:10430908 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:10430908 | pubmed:dateCreated | 1999-9-9 | lld:pubmed |
| pubmed-article:10430908 | pubmed:abstractText | Activation of CD40 is essential for thymus-dependent humoral immune responses and rescuing B cells from apoptosis. Many of the effects of CD40 are believed to be achieved through altered gene expression. In addition to Bcl-x, a known CD40-regulated antiapoptotic molecule, we identified a related antiapoptotic molecule, A1/Bfl-1, as a CD40-inducible gene. Inhibition of the NF-kappaB pathway by overexpression of a dominant-active inhibitor of NF-kappaB abolished CD40-induced up-regulation of both the Bfl-1 and Bcl-x genes and also eliminated the ability of CD40 to rescue Fas-induced cell death. Within the upstream promoter region of Bcl-x, a potential NF-kappaB-binding sequence was found to support NF-kappaB-dependent transcriptional activation. Furthermore, expression of physiological levels of Bcl-x protected B cells from Fas-mediated apoptosis in the absence of NF-kappaB signaling. Thus, our results suggest that CD40-mediated cell survival proceeds through NF-kappaB-dependent up-regulation of Bcl-2 family members. | lld:pubmed |
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| pubmed-article:10430908 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10430908 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10430908 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10430908 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10430908 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10430908 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10430908 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10430908 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10430908 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10430908 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:10430908 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:10430908 | pubmed:author | pubmed-author:ChengGG | lld:pubmed |
| pubmed-article:10430908 | pubmed:author | pubmed-author:LeeH HHH | lld:pubmed |
| pubmed-article:10430908 | pubmed:author | pubmed-author:ShuJJ | lld:pubmed |
| pubmed-article:10430908 | pubmed:author | pubmed-author:ChengQQ | lld:pubmed |
| pubmed-article:10430908 | pubmed:author | pubmed-author:DadgostarHH | lld:pubmed |
| pubmed-article:10430908 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10430908 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:10430908 | pubmed:volume | 96 | lld:pubmed |
| pubmed-article:10430908 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10430908 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10430908 | pubmed:pagination | 9136-41 | lld:pubmed |
| pubmed-article:10430908 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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