| pubmed-article:10426995 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10426995 | lifeskim:mentions | umls-concept:C0599840 | lld:lifeskim |
| pubmed-article:10426995 | lifeskim:mentions | umls-concept:C0023820 | lld:lifeskim |
| pubmed-article:10426995 | lifeskim:mentions | umls-concept:C0670896 | lld:lifeskim |
| pubmed-article:10426995 | lifeskim:mentions | umls-concept:C1512501 | lld:lifeskim |
| pubmed-article:10426995 | lifeskim:mentions | umls-concept:C1444748 | lld:lifeskim |
| pubmed-article:10426995 | pubmed:issue | 5428 | lld:pubmed |
| pubmed-article:10426995 | pubmed:dateCreated | 1999-8-16 | lld:pubmed |
| pubmed-article:10426995 | pubmed:abstractText | The generation of cell-mediated immunity against many infectious pathogens involves the production of interleukin-12 (IL-12), a key signal of the innate immune system. Yet, for many pathogens, the molecules that induce IL-12 production by macrophages and the mechanisms by which they do so remain undefined. Here it is shown that microbial lipoproteins are potent stimulators of IL-12 production by human macrophages, and that induction is mediated by Toll-like receptors (TLRs). Several lipoproteins stimulated TLR-dependent transcription of inducible nitric oxide synthase and the production of nitric oxide, a powerful microbicidal pathway. Activation of TLRs by microbial lipoproteins may initiate innate defense mechanisms against infectious pathogens. | lld:pubmed |
| pubmed-article:10426995 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10426995 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10426995 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10426995 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:10426995 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:10426995 | pubmed:author | pubmed-author:BloomB RBR | lld:pubmed |
| pubmed-article:10426995 | pubmed:author | pubmed-author:BrennanP JPJ | lld:pubmed |
| pubmed-article:10426995 | pubmed:author | pubmed-author:NorgardM VMV | lld:pubmed |
| pubmed-article:10426995 | pubmed:author | pubmed-author:KrutzikS RSR | lld:pubmed |
| pubmed-article:10426995 | pubmed:author | pubmed-author:SmallS MSM | lld:pubmed |
| pubmed-article:10426995 | pubmed:author | pubmed-author:ModlinR LRL | lld:pubmed |
| pubmed-article:10426995 | pubmed:author | pubmed-author:GodowskiP JPJ | lld:pubmed |
| pubmed-article:10426995 | pubmed:author | pubmed-author:LibratyD HDH | lld:pubmed |
| pubmed-article:10426995 | pubmed:author | pubmed-author:BelisleJ TJT | lld:pubmed |
| pubmed-article:10426995 | pubmed:author | pubmed-author:MaitlandMM | lld:pubmed |
| pubmed-article:10426995 | pubmed:author | pubmed-author:PlevyS ESE | lld:pubmed |
| pubmed-article:10426995 | pubmed:author | pubmed-author:YangR BRB | lld:pubmed |
| pubmed-article:10426995 | pubmed:author | pubmed-author:BrightbillH... | lld:pubmed |
| pubmed-article:10426995 | pubmed:author | pubmed-author:BleharskiJ... | lld:pubmed |
| pubmed-article:10426995 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10426995 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:10426995 | pubmed:volume | 285 | lld:pubmed |
| pubmed-article:10426995 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10426995 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10426995 | pubmed:pagination | 732-6 | lld:pubmed |
| pubmed-article:10426995 | pubmed:dateRevised | 2011-10-27 | lld:pubmed |
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| pubmed-article:10426995 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10426995 | pubmed:articleTitle | Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. | lld:pubmed |
| pubmed-article:10426995 | pubmed:affiliation | Department of Microbiology and Immunology, Howard Hughes Medical Institute, University of California Los Angeles School of Medicine, Los Anges, CA 90095, USA. | lld:pubmed |
| pubmed-article:10426995 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10426995 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10426995 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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