| pubmed-article:10410999 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10410999 | lifeskim:mentions | umls-concept:C0567416 | lld:lifeskim |
| pubmed-article:10410999 | lifeskim:mentions | umls-concept:C0018894 | lld:lifeskim |
| pubmed-article:10410999 | lifeskim:mentions | umls-concept:C0017968 | lld:lifeskim |
| pubmed-article:10410999 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10410999 | lifeskim:mentions | umls-concept:C0439859 | lld:lifeskim |
| pubmed-article:10410999 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:10410999 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:10410999 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:10410999 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10410999 | pubmed:dateCreated | 1999-8-13 | lld:pubmed |
| pubmed-article:10410999 | pubmed:abstractText | During inflammation, T helper cells transiently express class II major histocompatibility complex (MHC) glycoproteins and present antigens to other T cells. To assess involvement of self-antigens in the generation of T cell antigen-presenting cell (T-APC) activity, rat (R) myelin basic protein (MBP) was used to stimulate a rat CD4-CD8- T cell clone. RMBP induced T cell surface expression of class II MHC glycoproteins and T-APC activity, although RMBP did not elicit interleukin (IL-2) production or proliferation. When added to culture with the strong agonist guinea pig (GP) MBP, RMBP acted as a partial antagonist and inhibited responses of IL-2 production, proliferation, and T cell expression of B7.1. RMBP did not, however, efficiently antagonize GPMBP-induced I-A expression on T cells. These findings indicate that the self-antigen RMBP specifically induces accumulation of I-A/peptide complexes at signaling thresholds that inhibit pathogenic autoimmune responses. Overall, this study suggests a role for self-antigens in the generation of B7-deficient T-APC activity as a mechanism of tolerance in experimental autoimmune encephalomyelitis. | lld:pubmed |
| pubmed-article:10410999 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10410999 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10410999 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10410999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10410999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10410999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10410999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10410999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10410999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10410999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10410999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10410999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10410999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10410999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10410999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10410999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10410999 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10410999 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:10410999 | pubmed:issn | 0741-5400 | lld:pubmed |
| pubmed-article:10410999 | pubmed:author | pubmed-author:WhiteG AGA | lld:pubmed |
| pubmed-article:10410999 | pubmed:author | pubmed-author:WalkerM RMR | lld:pubmed |
| pubmed-article:10410999 | pubmed:author | pubmed-author:MannieM DMD | lld:pubmed |
| pubmed-article:10410999 | pubmed:author | pubmed-author:NardellaJ PJP | lld:pubmed |
| pubmed-article:10410999 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10410999 | pubmed:volume | 66 | lld:pubmed |
| pubmed-article:10410999 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10410999 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10410999 | pubmed:pagination | 120-6 | lld:pubmed |
| pubmed-article:10410999 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10410999 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10410999 | pubmed:articleTitle | An autologous self-antigen differentially regulates expression of I-A glycoproteins and B7 costimulatory molecules on CD4- CD8- T helper cells. | lld:pubmed |
| pubmed-article:10410999 | pubmed:affiliation | Department of Microbiology and Immunology, East Carolina University School of Medicine, Greenville, North Carolina 27858-4354, USA. | lld:pubmed |
| pubmed-article:10410999 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10410999 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
