| pubmed-article:10400737 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10400737 | lifeskim:mentions | umls-concept:C0020094 | lld:lifeskim |
| pubmed-article:10400737 | lifeskim:mentions | umls-concept:C0086427 | lld:lifeskim |
| pubmed-article:10400737 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:10400737 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:10400737 | lifeskim:mentions | umls-concept:C0560175 | lld:lifeskim |
| pubmed-article:10400737 | lifeskim:mentions | umls-concept:C0039371 | lld:lifeskim |
| pubmed-article:10400737 | lifeskim:mentions | umls-concept:C0205132 | lld:lifeskim |
| pubmed-article:10400737 | lifeskim:mentions | umls-concept:C2348628 | lld:lifeskim |
| pubmed-article:10400737 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:10400737 | pubmed:dateCreated | 1999-8-24 | lld:pubmed |
| pubmed-article:10400737 | pubmed:abstractText | Human T-cell leukemia virus type 1 (HTLV-1) causes T-cell malignancies in a small percentage of the population infected with the virus after a long carrier state. In the present study, we established a seronegative HTLV-1 carrier state in rats inoculated with a newly established HTLV-1-infected rat T cell line, FPM1. FPM1 originated from rat thymocytes cocultured with a human HTLV-1 producer, MT-2 cells, and expressed rat CD4, CD5, CD25, and HTLV-1 Tax. However, FPM1 scarcely expressed other major HTLV-1 structural proteins and failed to induce typical antibody responses against HTLV-1 in inoculated rats. In contrast, control rats inoculated with MT-2 cells generated significant levels of anti-HTLV-1 antibodies. HTLV-1 proviruses were detected in peripheral blood cells of syngeneic rats inoculated with FPM1 for more than 1 year. Analysis of the flanking region of HTLV-1 provirus integrated into host cells suggested that FPM1 cells remained in these animals over a relatively long period of time. However, a similar seronegative HTLV-1 carrier state was induced in the rats inoculated with mitomycin C-treated FPM1 cells and also in FPM1-inoculated allogeneic rats, suggesting that FPM1 could also transmit HTLV-1 into host cells in vivo. Our findings indicated that (i) HTLV-1-immortalized T cells which preferentially express HTLV-1 Tax persisted in vivo but failed to induce any diseases in immunocompetent syngeneic rats and that (ii) suboptimal levels of HTLV-1 for antibody responses allowed the establishment of persistent HTLV-1 infection. | lld:pubmed |
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| pubmed-article:10400737 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10400737 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10400737 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10400737 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10400737 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10400737 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:10400737 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:10400737 | pubmed:author | pubmed-author:OhashiTT | lld:pubmed |
| pubmed-article:10400737 | pubmed:author | pubmed-author:MatsuokaMM | lld:pubmed |
| pubmed-article:10400737 | pubmed:author | pubmed-author:KatzEE | lld:pubmed |
| pubmed-article:10400737 | pubmed:author | pubmed-author:FujiiMM | lld:pubmed |
| pubmed-article:10400737 | pubmed:author | pubmed-author:TsukaharaTT | lld:pubmed |
| pubmed-article:10400737 | pubmed:author | pubmed-author:KannagiMM | lld:pubmed |
| pubmed-article:10400737 | pubmed:author | pubmed-author:EtohKK | lld:pubmed |
| pubmed-article:10400737 | pubmed:author | pubmed-author:TakemuraFF | lld:pubmed |
| pubmed-article:10400737 | pubmed:author | pubmed-author:KoyaYY | lld:pubmed |
| pubmed-article:10400737 | pubmed:author | pubmed-author:HanabuchiSS | lld:pubmed |
| pubmed-article:10400737 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10400737 | pubmed:volume | 73 | lld:pubmed |
| pubmed-article:10400737 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10400737 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10400737 | pubmed:pagination | 6436-43 | lld:pubmed |
| pubmed-article:10400737 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:10400737 | pubmed:meshHeading | pubmed-meshheading:10400737... | lld:pubmed |
| pubmed-article:10400737 | pubmed:meshHeading | pubmed-meshheading:10400737... | lld:pubmed |
