| pubmed-article:10395688 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10395688 | lifeskim:mentions | umls-concept:C0003451 | lld:lifeskim |
| pubmed-article:10395688 | lifeskim:mentions | umls-concept:C0385242 | lld:lifeskim |
| pubmed-article:10395688 | lifeskim:mentions | umls-concept:C1720948 | lld:lifeskim |
| pubmed-article:10395688 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:10395688 | lifeskim:mentions | umls-concept:C1336646 | lld:lifeskim |
| pubmed-article:10395688 | lifeskim:mentions | umls-concept:C0597360 | lld:lifeskim |
| pubmed-article:10395688 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:10395688 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:10395688 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:10395688 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:10395688 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10395688 | pubmed:dateCreated | 1999-7-29 | lld:pubmed |
| pubmed-article:10395688 | pubmed:abstractText | TNF-related apoptosis-inducing ligand (TRAIL) is able to kill many transformed cells of diverse tissue types. We show that TRAIL is inducible by IFN-gamma, by TNF-alpha, and by infection with human CMV, and has potent antiviral activity in vitro. CMV infection and IFN-gamma also reciprocally modulate TRAIL receptor (TRAIL-R) expression. CMV infection increased the expression of TRAIL-R1 and -R2, whereas IFN-gamma down-regulated the expression of TRAIL-Rs on uninfected fibroblasts. Moreover, IFN-gamma significantly decreased the basal level of NF-kappaB activation, a known survival factor that inhibits apoptosis. Thus, TRAIL selectively kills virus-infected cells while leaving uninfected cells intact, and IFN-gamma potentiates these effects by dynamic modulation of TRAIL and TRAIL-R expression and by sensitizing cells to apoptosis. The regulation of TRAIL and TRAIL-R expression may represent a general mechanism that contributes to the control of TRAIL-mediated apoptosis. | lld:pubmed |
| pubmed-article:10395688 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10395688 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10395688 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:10395688 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10395688 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:10395688 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:10395688 | pubmed:author | pubmed-author:BlantonR ARA | lld:pubmed |
| pubmed-article:10395688 | pubmed:author | pubmed-author:GoodwinR GRG | lld:pubmed |
| pubmed-article:10395688 | pubmed:author | pubmed-author:WileyS RSR | lld:pubmed |
| pubmed-article:10395688 | pubmed:author | pubmed-author:PeschonJ JJJ | lld:pubmed |
| pubmed-article:10395688 | pubmed:author | pubmed-author:CosmanDD | lld:pubmed |
| pubmed-article:10395688 | pubmed:author | pubmed-author:SedgerL MLM | lld:pubmed |
| pubmed-article:10395688 | pubmed:author | pubmed-author:ShowsD MDM | lld:pubmed |
| pubmed-article:10395688 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10395688 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:10395688 | pubmed:volume | 163 | lld:pubmed |
| pubmed-article:10395688 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10395688 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10395688 | pubmed:pagination | 920-6 | lld:pubmed |
| pubmed-article:10395688 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:10395688 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10395688 | pubmed:articleTitle | IFN-gamma mediates a novel antiviral activity through dynamic modulation of TRAIL and TRAIL receptor expression. | lld:pubmed |
| pubmed-article:10395688 | pubmed:affiliation | Department of Molecular Immunology, Immunex Corporation, Seattle, WA 98101, USA. sedger1@immunex.com | lld:pubmed |
| pubmed-article:10395688 | pubmed:publicationType | Journal Article | lld:pubmed |
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