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| pubmed-article:10376879 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
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| pubmed-article:10376879 | lifeskim:mentions | umls-concept:C0040715 | lld:lifeskim |
| pubmed-article:10376879 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:10376879 | lifeskim:mentions | umls-concept:C1522702 | lld:lifeskim |
| pubmed-article:10376879 | lifeskim:mentions | umls-concept:C1519249 | lld:lifeskim |
| pubmed-article:10376879 | lifeskim:mentions | umls-concept:C0599718 | lld:lifeskim |
| pubmed-article:10376879 | lifeskim:mentions | umls-concept:C0599813 | lld:lifeskim |
| pubmed-article:10376879 | lifeskim:mentions | umls-concept:C0599893 | lld:lifeskim |
| pubmed-article:10376879 | lifeskim:mentions | umls-concept:C1705994 | lld:lifeskim |
| pubmed-article:10376879 | lifeskim:mentions | umls-concept:C1706470 | lld:lifeskim |
| pubmed-article:10376879 | lifeskim:mentions | umls-concept:C1706469 | lld:lifeskim |
| pubmed-article:10376879 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:10376879 | lifeskim:mentions | umls-concept:C1513492 | lld:lifeskim |
| pubmed-article:10376879 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:10376879 | lifeskim:mentions | umls-concept:C0596448 | lld:lifeskim |
| pubmed-article:10376879 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:10376879 | pubmed:dateCreated | 1999-6-29 | lld:pubmed |
| pubmed-article:10376879 | pubmed:abstractText | Translocation of DNA or RNA is a ubiquitous phenomenon. One intricate translocation process is viral DNA packaging. During maturation, the lengthy genome of dsDNA viruses is translocated with remarkable velocity into a limited space within the procapsid. We have revealed that phi29 DNA packaging is accomplished by a mechanism similar to driving a bolt with a hex nut, which consists of six DNA-packaging pRNAs. Four bases in each of the two pRNA loops are involved in RNA/RNA interactions to form a hexagonal complex that gears the DNA translocating machine. Without considering the tertiary interaction, in some cases only two G/C pairs between the interacting loops could provide certain pRNAs with activity. When all four bases were paired, at least one G/C pair was required for DNA packaging. The maximum number of base pairings between the two loops to allow pRNA to retain wild-type activity was five, whereas the minimum number was five for one loop and three for the other. The findings were supported by phylogenetic analysis of seven pRNAs from different phages. A 75-base RNA segment, bases 23-97, was able to form dimer, to interlock into the hexamer, to compete with full-length pRNA for procapsid binding, and therefore to inhibit phi29 assembly in vitro. Our result suggests that segment 23-97 is a self-folded, independent domain involved in procapsid binding and RNA/RNA interaction in dimer and hexamer formation, whereas bases 1-22 and 98-120 are involved in DNA translocation but dispensable for RNA/RNA interaction. Therefore, this 75-base RNA could be a model for structural studies in RNA dimerization. | lld:pubmed |
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| pubmed-article:10376879 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10376879 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10376879 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10376879 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10376879 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10376879 | pubmed:issn | 1355-8382 | lld:pubmed |
| pubmed-article:10376879 | pubmed:author | pubmed-author:ChenCC | lld:pubmed |
| pubmed-article:10376879 | pubmed:author | pubmed-author:GutWW | lld:pubmed |
| pubmed-article:10376879 | pubmed:author | pubmed-author:ZhangCC | lld:pubmed |
| pubmed-article:10376879 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10376879 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:10376879 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10376879 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10376879 | pubmed:pagination | 805-18 | lld:pubmed |
| pubmed-article:10376879 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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