| pubmed-article:10373528 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10373528 | lifeskim:mentions | umls-concept:C0017355 | lld:lifeskim |
| pubmed-article:10373528 | lifeskim:mentions | umls-concept:C0024518 | lld:lifeskim |
| pubmed-article:10373528 | lifeskim:mentions | umls-concept:C0076925 | lld:lifeskim |
| pubmed-article:10373528 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:10373528 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:10373528 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10373528 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:10373528 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:10373528 | pubmed:dateCreated | 1999-7-22 | lld:pubmed |
| pubmed-article:10373528 | pubmed:abstractText | The tissue-specific expression of major histocompatibility complex class I genes is determined by a series of upstream regulatory elements, many of which remain ill defined. We now report that a distal E-box element, located between bp -309 and -314 upstream of transcription initiation, acts as a cell type-specific enhancer of class I promoter activity. The class I E box is very active in a neuroblastoma cell line, CHP-126, but is relatively inactive in the HeLa epithelial cell line. The basic helix-loop-helix leucine zipper proteins upstream stimulatory factor 1 (USF1) and USF2 were shown to specifically recognize the class I E box, resulting in the activation of the downstream promoter. Fine mapping of USF1 and USF2 amino-terminal functional domains revealed differences in their abilities to activate the class I E box. Whereas USF1 contained only an extended activation domain, USF2 contained both an activation domain and a negative regulatory region. Surprisingly, the naturally occurring splice variant of USF2 lacking the exon 4 domain, U2DeltaE4, acted as a dominant-negative regulator of USF-mediated activation of the class I promoter. This latter activity is in sharp contrast to the known ability of U2DeltaE4 to activate the adenovirus major late promoter. Class I E-box function is correlated with the relative amount of U2DeltaE4 in a cell, leading to the proposal that U2DeltaE4 modulates class I E-box activity and may represent one mechanism to fine-tune class I expression in various tissues. | lld:pubmed |
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| pubmed-article:10373528 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10373528 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10373528 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10373528 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10373528 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:10373528 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:10373528 | pubmed:author | pubmed-author:MurphyCC | lld:pubmed |
| pubmed-article:10373528 | pubmed:author | pubmed-author:SingerD SDS | lld:pubmed |
| pubmed-article:10373528 | pubmed:author | pubmed-author:WeissmanJ DJD | lld:pubmed |
| pubmed-article:10373528 | pubmed:author | pubmed-author:SawadogoMM | lld:pubmed |
| pubmed-article:10373528 | pubmed:author | pubmed-author:HuberS JSJ | lld:pubmed |
| pubmed-article:10373528 | pubmed:author | pubmed-author:HowcroftT KTK | lld:pubmed |
| pubmed-article:10373528 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10373528 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:10373528 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10373528 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10373528 | pubmed:pagination | 4788-97 | lld:pubmed |
| pubmed-article:10373528 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:10373528 | pubmed:meshHeading | pubmed-meshheading:10373528... | lld:pubmed |
| pubmed-article:10373528 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10373528 | pubmed:articleTitle | Upstream stimulatory factor regulates major histocompatibility complex class I gene expression: the U2DeltaE4 splice variant abrogates E-box activity. | lld:pubmed |
| pubmed-article:10373528 | pubmed:affiliation | Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1360, USA. Howcrofk@Exchange.nih.gov | lld:pubmed |
| pubmed-article:10373528 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10373528 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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