| pubmed-article:10369687 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10369687 | lifeskim:mentions | umls-concept:C0034865 | lld:lifeskim |
| pubmed-article:10369687 | lifeskim:mentions | umls-concept:C0021027 | lld:lifeskim |
| pubmed-article:10369687 | lifeskim:mentions | umls-concept:C0001721 | lld:lifeskim |
| pubmed-article:10369687 | lifeskim:mentions | umls-concept:C0879290 | lld:lifeskim |
| pubmed-article:10369687 | lifeskim:mentions | umls-concept:C0205276 | lld:lifeskim |
| pubmed-article:10369687 | lifeskim:mentions | umls-concept:C0011155 | lld:lifeskim |
| pubmed-article:10369687 | lifeskim:mentions | umls-concept:C1519249 | lld:lifeskim |
| pubmed-article:10369687 | lifeskim:mentions | umls-concept:C0013682 | lld:lifeskim |
| pubmed-article:10369687 | lifeskim:mentions | umls-concept:C0037791 | lld:lifeskim |
| pubmed-article:10369687 | lifeskim:mentions | umls-concept:C2348042 | lld:lifeskim |
| pubmed-article:10369687 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:10369687 | pubmed:dateCreated | 1999-8-19 | lld:pubmed |
| pubmed-article:10369687 | pubmed:abstractText | During maturation of the immune response, IgM+ B cells switch to expression of one of the downstream isotypes (IgG, A or E). This class switching occurs by region-specific recombination within the IgH locus through an unknown mechanism. A lack of switch recombination in mice deficient in components of the DNA-dependent protein kinase (DNA-PK)-Ku complex has pointed to a role for non-homologous end joining. Here we characterize a switching defect in mice lacking a protein involved in DNA mismatch recognition. Mice deficient in Msh2 give diminished IgG (but not IgM) responses following challenge with both T cell-dependent and T cell-independent antigens. This appears to reflect a B cell-intrinsic defect since B cells from Msh2-deficient mice also exhibit impaired switching (but not blasting or proliferation) on in vitro culture with lipopolysaccharide. Furthermore, those switches that do occur in Msh2-deficient B cells reveal a shift in the distribution of recombination sites used: the breakpoints are more likely to occur in consensus motifs. These results, which intriguingly parallel the effects of Msh2 deficiency on hypermutation, suggest a role for Msh2 in the mechanics of class-switch recombination. | lld:pubmed |
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| pubmed-article:10369687 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10369687 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10369687 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10369687 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10369687 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10369687 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:10369687 | pubmed:author | pubmed-author:NeubergerM... | lld:pubmed |
| pubmed-article:10369687 | pubmed:author | pubmed-author:EhrensteinM... | lld:pubmed |
| pubmed-article:10369687 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10369687 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:10369687 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:10369687 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10369687 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10369687 | pubmed:pagination | 3484-90 | lld:pubmed |
| pubmed-article:10369687 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:10369687 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10369687 | pubmed:articleTitle | Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation. | lld:pubmed |
| pubmed-article:10369687 | pubmed:affiliation | Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK. | lld:pubmed |
| pubmed-article:10369687 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:17685 | entrezgene:pubmed | pubmed-article:10369687 | lld:entrezgene |
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