| pubmed-article:10364429 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10364429 | lifeskim:mentions | umls-concept:C0035668 | lld:lifeskim |
| pubmed-article:10364429 | lifeskim:mentions | umls-concept:C0441471 | lld:lifeskim |
| pubmed-article:10364429 | lifeskim:mentions | umls-concept:C0678723 | lld:lifeskim |
| pubmed-article:10364429 | lifeskim:mentions | umls-concept:C0449243 | lld:lifeskim |
| pubmed-article:10364429 | lifeskim:mentions | umls-concept:C0162610 | lld:lifeskim |
| pubmed-article:10364429 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:10364429 | lifeskim:mentions | umls-concept:C0458003 | lld:lifeskim |
| pubmed-article:10364429 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10364429 | pubmed:dateCreated | 1999-7-1 | lld:pubmed |
| pubmed-article:10364429 | pubmed:abstractText | The lin-4 gene encodes a small RNA that is required to translationally repress lin-14 toward the end of the first larval stage of Caenorhabditis elegans development. To determine if the timing of LIN-14 protein down-regulation depends on the temporal profile of lin-4 RNA level, we analyzed the stage-specificity of lin-4 RNA expression during wild-type development and examined the phenotypes of transgenic worms that overexpress lin-4 RNA during the first larval stage. We found that lin-4 RNA first becomes detectable at approximately 12 h of wild-type larval development and rapidly accumulates to nearly maximum levels by 16 h. This profile of lin-4 RNA accumulation corresponded to the timing of LIN-14 protein down-regulation. Transgenic strains that express elevated levels of lin-4 RNA prior to 12 h of development display reduced levels of LIN-14 protein and precocious phenotypes consistent with abnormally early loss of lin-14 activity. These results indicate that the temporal profile of lin-4 RNA accumulation specifies the timing of LIN-14 down-regulation and thereby controls the timing of postembryonic developmental events. | lld:pubmed |
| pubmed-article:10364429 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10364429 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10364429 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10364429 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10364429 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10364429 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10364429 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10364429 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10364429 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10364429 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10364429 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10364429 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10364429 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10364429 | pubmed:issn | 0012-1606 | lld:pubmed |
| pubmed-article:10364429 | pubmed:author | pubmed-author:AmbrosVV | lld:pubmed |
| pubmed-article:10364429 | pubmed:author | pubmed-author:FeinbaumRR | lld:pubmed |
| pubmed-article:10364429 | pubmed:copyrightInfo | Copyright 1999 Academic Press. | lld:pubmed |
| pubmed-article:10364429 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10364429 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10364429 | pubmed:volume | 210 | lld:pubmed |
| pubmed-article:10364429 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10364429 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10364429 | pubmed:pagination | 87-95 | lld:pubmed |
| pubmed-article:10364429 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:10364429 | pubmed:meshHeading | pubmed-meshheading:10364429... | lld:pubmed |
| pubmed-article:10364429 | pubmed:meshHeading | pubmed-meshheading:10364429... | lld:pubmed |
| pubmed-article:10364429 | pubmed:meshHeading | pubmed-meshheading:10364429... | lld:pubmed |
| pubmed-article:10364429 | pubmed:meshHeading | pubmed-meshheading:10364429... | lld:pubmed |
| pubmed-article:10364429 | pubmed:meshHeading | pubmed-meshheading:10364429... | lld:pubmed |
| pubmed-article:10364429 | pubmed:meshHeading | pubmed-meshheading:10364429... | lld:pubmed |
| pubmed-article:10364429 | pubmed:meshHeading | pubmed-meshheading:10364429... | lld:pubmed |
| pubmed-article:10364429 | pubmed:meshHeading | pubmed-meshheading:10364429... | lld:pubmed |
| pubmed-article:10364429 | pubmed:meshHeading | pubmed-meshheading:10364429... | lld:pubmed |
| pubmed-article:10364429 | pubmed:meshHeading | pubmed-meshheading:10364429... | lld:pubmed |
| pubmed-article:10364429 | pubmed:meshHeading | pubmed-meshheading:10364429... | lld:pubmed |
| pubmed-article:10364429 | pubmed:meshHeading | pubmed-meshheading:10364429... | lld:pubmed |
| pubmed-article:10364429 | pubmed:meshHeading | pubmed-meshheading:10364429... | lld:pubmed |
| pubmed-article:10364429 | pubmed:meshHeading | pubmed-meshheading:10364429... | lld:pubmed |
| pubmed-article:10364429 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10364429 | pubmed:articleTitle | The timing of lin-4 RNA accumulation controls the timing of postembryonic developmental events in Caenorhabditis elegans. | lld:pubmed |
| pubmed-article:10364429 | pubmed:affiliation | Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, 02114, USA. | lld:pubmed |
| pubmed-article:10364429 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10364429 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10364429 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:266860 | entrezgene:pubmed | pubmed-article:10364429 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10364429 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10364429 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10364429 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10364429 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10364429 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10364429 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10364429 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10364429 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10364429 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10364429 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10364429 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10364429 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10364429 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10364429 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10364429 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10364429 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10364429 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10364429 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10364429 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10364429 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10364429 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10364429 | lld:pubmed |
