| pubmed-article:10363802 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10363802 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:10363802 | lifeskim:mentions | umls-concept:C1522564 | lld:lifeskim |
| pubmed-article:10363802 | lifeskim:mentions | umls-concept:C0002508 | lld:lifeskim |
| pubmed-article:10363802 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:10363802 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:10363802 | lifeskim:mentions | umls-concept:C0243144 | lld:lifeskim |
| pubmed-article:10363802 | lifeskim:mentions | umls-concept:C0077281 | lld:lifeskim |
| pubmed-article:10363802 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10363802 | pubmed:dateCreated | 1999-7-29 | lld:pubmed |
| pubmed-article:10363802 | pubmed:abstractText | Previous research into development of a gallium-radiolabeled agent that crosses the blood-brain barrier has met with limited success. In this study, we focused our attention on a Ga(III) complex of a 4-coordinate amine trithiolate tripod ligand, tris(2-mercaptobenzyl) amine (S3N). The Ga(III) S3N complex is small, neutral, and lipophilic, meeting the requirements for a potential brain imaging agent. The Ga-68 complex was easily formed with a radiochemical purity of >95%. In vitro stability of the Ga-S3N complex, determined in rat serum incubated at 37 degrees C, was greater than 95% intact at 2 h by silica gel and reversed-phase radio-thin layer chromatography. Biodistribution studies conducted in female Sprague-Dawley rats showed the complex cleared rapidly from the blood with initial high liver uptake followed by rapid washout. Significant uptake was observed in the brain, with brain:blood ratios increasing from 0.11 at 2 min postinjection to 3.8 at 60 min postinjection. Uptake was also observed in the heart going from a heart:blood ratio of 2.3 at 2 min postinjection to 11 at 60 min postinjection. Molecular mechanics were used to determine the coordination number, and demonstrated that the Ga(III) complex prefers to be 4-coordinate. Imaging studies with 68Ga-S3N in a Nemestrina macaque showed significant brain uptake, similar to other lipophilic agents. The extraction of 68Ga-S3N into the brains of both rodents and primates, higher than any 68Ga agent reported in the literature, suggests that this compound may have potential as a brain imaging agent for positron emission tomography. | lld:pubmed |
| pubmed-article:10363802 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10363802 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10363802 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10363802 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10363802 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10363802 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10363802 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10363802 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10363802 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10363802 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10363802 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10363802 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:10363802 | pubmed:issn | 0969-8051 | lld:pubmed |
| pubmed-article:10363802 | pubmed:author | pubmed-author:WelchM JMJ | lld:pubmed |
| pubmed-article:10363802 | pubmed:author | pubmed-author:HerreroPP | lld:pubmed |
| pubmed-article:10363802 | pubmed:author | pubmed-author:AndersonC JCJ | lld:pubmed |
| pubmed-article:10363802 | pubmed:author | pubmed-author:KochS ASA | lld:pubmed |
| pubmed-article:10363802 | pubmed:author | pubmed-author:SnyderA ZAZ | lld:pubmed |
| pubmed-article:10363802 | pubmed:author | pubmed-author:CutlerC SCS | lld:pubmed |
| pubmed-article:10363802 | pubmed:author | pubmed-author:ReichertD EDE | lld:pubmed |
| pubmed-article:10363802 | pubmed:author | pubmed-author:GironM CMC | lld:pubmed |
| pubmed-article:10363802 | pubmed:author | pubmed-author:QuarlessD ADA | lld:pubmed |
| pubmed-article:10363802 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10363802 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:10363802 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10363802 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10363802 | pubmed:pagination | 305-16 | lld:pubmed |
| pubmed-article:10363802 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10363802 | pubmed:meshHeading | pubmed-meshheading:10363802... | lld:pubmed |
| pubmed-article:10363802 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10363802 | pubmed:articleTitle | Evaluation of gallium-68 tris(2-mercaptobenzyl)amine: a complex with brain and myocardial uptake. | lld:pubmed |
| pubmed-article:10363802 | pubmed:affiliation | The Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA. | lld:pubmed |
| pubmed-article:10363802 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10363802 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:10363802 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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