| pubmed-article:10362508 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10362508 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:10362508 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:10362508 | lifeskim:mentions | umls-concept:C0022131 | lld:lifeskim |
| pubmed-article:10362508 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
| pubmed-article:10362508 | lifeskim:mentions | umls-concept:C0030055 | lld:lifeskim |
| pubmed-article:10362508 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:10362508 | lifeskim:mentions | umls-concept:C0205171 | lld:lifeskim |
| pubmed-article:10362508 | lifeskim:mentions | umls-concept:C0449774 | lld:lifeskim |
| pubmed-article:10362508 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10362508 | pubmed:dateCreated | 1999-6-28 | lld:pubmed |
| pubmed-article:10362508 | pubmed:abstractText | A novel oxygen microsensor was used to measure oxygen levels in single mouse islets as a function of glucose concentration. Oxygen consumption of individual islets was 5.99 +/- 1.17, 9.21 +/- 2.15, and 12.22 +/- 2.16 pmol/min at 3, 10, and 20 mM glucose, respectively (mean +/- SEM, n = 10). Consumption of oxygen was islet-size dependent as larger islets consumed more oxygen than smaller islets but smaller islets consumed more oxygen per unit volume than larger islets. Elevating glucose levels from 3 to 10 mM induced pronounced fast oscillations in oxygen level (period of 12.1 +/- 1.7 s, n = 6) superimposed on top of large slow oscillations (period of 3.3 +/- 0.6 min, n = 6). The fast oscillations could be completely abolished by treatment with the L-type Ca2+-channel blocker nifedipine (40 microM) with a lesser effect on slow oscillations. Slow oscillations were almost completely dependent upon extracellular Ca2+. The oxygen patterns closely mimic those that have previously been reported for intracellular Ca2+ levels and are suggestive of an important role for Ca2+ in amplifying metabolic oscillations. | lld:pubmed |
| pubmed-article:10362508 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10362508 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10362508 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10362508 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10362508 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10362508 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10362508 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10362508 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10362508 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10362508 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:10362508 | pubmed:author | pubmed-author:JungS KSK | lld:pubmed |
| pubmed-article:10362508 | pubmed:author | pubmed-author:KennedyR TRT | lld:pubmed |
| pubmed-article:10362508 | pubmed:author | pubmed-author:AspinwallC... | lld:pubmed |
| pubmed-article:10362508 | pubmed:copyrightInfo | Copyright 1999 Academic Press. | lld:pubmed |
| pubmed-article:10362508 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10362508 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:10362508 | pubmed:volume | 259 | lld:pubmed |
| pubmed-article:10362508 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10362508 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10362508 | pubmed:pagination | 331-5 | lld:pubmed |
| pubmed-article:10362508 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:10362508 | pubmed:meshHeading | pubmed-meshheading:10362508... | lld:pubmed |
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| pubmed-article:10362508 | pubmed:meshHeading | pubmed-meshheading:10362508... | lld:pubmed |
| pubmed-article:10362508 | pubmed:meshHeading | pubmed-meshheading:10362508... | lld:pubmed |
| pubmed-article:10362508 | pubmed:meshHeading | pubmed-meshheading:10362508... | lld:pubmed |
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| pubmed-article:10362508 | pubmed:meshHeading | pubmed-meshheading:10362508... | lld:pubmed |
| pubmed-article:10362508 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10362508 | pubmed:articleTitle | Detection of multiple patterns of oscillatory oxygen consumption in single mouse islets of Langerhans. | lld:pubmed |
| pubmed-article:10362508 | pubmed:affiliation | Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, USA. | lld:pubmed |
| pubmed-article:10362508 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10362508 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10362508 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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