| pubmed-article:10344463 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10344463 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:10344463 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:10344463 | lifeskim:mentions | umls-concept:C0271510 | lld:lifeskim |
| pubmed-article:10344463 | lifeskim:mentions | umls-concept:C1335808 | lld:lifeskim |
| pubmed-article:10344463 | lifeskim:mentions | umls-concept:C0599946 | lld:lifeskim |
| pubmed-article:10344463 | lifeskim:mentions | umls-concept:C0439578 | lld:lifeskim |
| pubmed-article:10344463 | lifeskim:mentions | umls-concept:C0332206 | lld:lifeskim |
| pubmed-article:10344463 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:10344463 | pubmed:dateCreated | 1999-7-20 | lld:pubmed |
| pubmed-article:10344463 | pubmed:abstractText | Exercise induces a selective redistribution of CD62L(-) T lymphocytes. This study examined the effects of beta adrenergic receptor blockade on this phenomenon. Twelve healthy men were exercised to exhaustion on a treadmill prior to and following 1 week of treatment with the nonselective beta antagonist propranolol or the beta1 selective antagonist metoprolol. Dynamic exercise resulted in a significant lymphocytosis (p < 0.001). CD8(+)CD62L(-) T cells showed a greater than 3-fold increase in response to exercise (p < 0.001) as compared to CD8(+)CD62L(+) T cells, which showed a more modest increase. Treatment with the nonselective beta antagonist propranolol significantly attenuated the preferential increase of circulating CD8(+)CD62L(-) lymphocytes (p = 0.01) but had no effect on CD8(+)CD62L(+) T cells. Treatment with the beta1 selective antagonist metoprolol did not affect the response of either subset. Our findings replicate a prior study indicating that CD62L expression influences T lymphocyte trafficking in response to exercise and extends those findings by showing that this phenomenon is mediated, in part, via the beta2-adrenergic receptor. | lld:pubmed |
| pubmed-article:10344463 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10344463 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10344463 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10344463 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10344463 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10344463 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10344463 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10344463 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10344463 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10344463 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10344463 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10344463 | pubmed:month | May | lld:pubmed |
| pubmed-article:10344463 | pubmed:issn | 0301-5548 | lld:pubmed |
| pubmed-article:10344463 | pubmed:author | pubmed-author:ZieglerM GMG | lld:pubmed |
| pubmed-article:10344463 | pubmed:author | pubmed-author:CarterS MSM | lld:pubmed |
| pubmed-article:10344463 | pubmed:author | pubmed-author:DimsdaleJ EJE | lld:pubmed |
| pubmed-article:10344463 | pubmed:author | pubmed-author:MaiselA SAS | lld:pubmed |
| pubmed-article:10344463 | pubmed:author | pubmed-author:MillsP JPJ | lld:pubmed |
| pubmed-article:10344463 | pubmed:author | pubmed-author:RehmanJJ | lld:pubmed |
| pubmed-article:10344463 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10344463 | pubmed:volume | 79 | lld:pubmed |
| pubmed-article:10344463 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10344463 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10344463 | pubmed:pagination | 531-4 | lld:pubmed |
| pubmed-article:10344463 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:10344463 | pubmed:meshHeading | pubmed-meshheading:10344463... | lld:pubmed |
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| pubmed-article:10344463 | pubmed:meshHeading | pubmed-meshheading:10344463... | lld:pubmed |
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| pubmed-article:10344463 | pubmed:meshHeading | pubmed-meshheading:10344463... | lld:pubmed |
| pubmed-article:10344463 | pubmed:meshHeading | pubmed-meshheading:10344463... | lld:pubmed |
| pubmed-article:10344463 | pubmed:meshHeading | pubmed-meshheading:10344463... | lld:pubmed |
| pubmed-article:10344463 | pubmed:meshHeading | pubmed-meshheading:10344463... | lld:pubmed |
| pubmed-article:10344463 | pubmed:meshHeading | pubmed-meshheading:10344463... | lld:pubmed |
| pubmed-article:10344463 | pubmed:meshHeading | pubmed-meshheading:10344463... | lld:pubmed |
| pubmed-article:10344463 | pubmed:meshHeading | pubmed-meshheading:10344463... | lld:pubmed |
| pubmed-article:10344463 | pubmed:meshHeading | pubmed-meshheading:10344463... | lld:pubmed |
| pubmed-article:10344463 | pubmed:meshHeading | pubmed-meshheading:10344463... | lld:pubmed |
| pubmed-article:10344463 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10344463 | pubmed:articleTitle | Nonselective beta blockade attenuates the recruitment of CD62L(-)T lymphocytes following exercise. | lld:pubmed |
| pubmed-article:10344463 | pubmed:affiliation | Department of Psychiatry, University of California, San Diego, USA. pmills@ucsd.edu | lld:pubmed |
| pubmed-article:10344463 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10344463 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10344463 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10344463 | lld:pubmed |
