| pubmed-article:10233745 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10233745 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10233745 | lifeskim:mentions | umls-concept:C1522642 | lld:lifeskim |
| pubmed-article:10233745 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:10233745 | lifeskim:mentions | umls-concept:C1819882 | lld:lifeskim |
| pubmed-article:10233745 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:10233745 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:10233745 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:10233745 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:10233745 | pubmed:dateCreated | 1999-7-30 | lld:pubmed |
| pubmed-article:10233745 | pubmed:abstractText | Monoclonal antibodies (mAb) specific for the clonotype of an autoreactive T cell may be useful reagents in the modulation of autoimmune disease. We have previously reported the generation of a set of mAb specific for the clonotypic structure of a human T-cell clone recognizing an epitope of human cartilage gp-39. This glycoprotein was recently identified as a candidate autoantigen in rheumatoid arthritis. Here, we demonstrate for the first time that small amounts of immobilized anticlonotype mAb can induce anergy in the autoreactive clone. Following the anergic stimulus, T cells failed to proliferate upon restimulation as a result of a lack of interleukin-2 (IL-2) gene transcription. In addition, a diminished interferon-gamma (IFN-gamma) production was found. Our data indicate that anergy was not a result of T-cell receptor (TCR) downmodulation or the absence of free TCR. The anergic state was induced independent of costimulation or the presence of IL-2 and no protein synthesis was required for the induction of anergy. Anticlonotype mAb-induced anergy was prevented by cyclosporin A, suggesting that active signalling via the calcium/calcineurin pathway was required for the induction of anergy. In coculture experiments, anergic T cells were found to suppress the response of reactive cells from the same clone. This bystander suppression led to 90% inhibition of peptide-induced proliferation. Together, these findings suggest that mAb to the clonotypic structure of autoreactive T cells may be suitable reagents for the functional inactivation of these T cells in autoimmune diseases. | lld:pubmed |
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| pubmed-article:10233745 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10233745 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10233745 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10233745 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10233745 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10233745 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10233745 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10233745 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:10233745 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:10233745 | pubmed:author | pubmed-author:BootsA MAM | lld:pubmed |
| pubmed-article:10233745 | pubmed:author | pubmed-author:SteenbakkersP... | lld:pubmed |
| pubmed-article:10233745 | pubmed:author | pubmed-author:RijndersA WAW | lld:pubmed |
| pubmed-article:10233745 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10233745 | pubmed:volume | 96 | lld:pubmed |
| pubmed-article:10233745 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10233745 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10233745 | pubmed:pagination | 586-94 | lld:pubmed |
| pubmed-article:10233745 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:10233745 | pubmed:meshHeading | pubmed-meshheading:10233745... | lld:pubmed |
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| pubmed-article:10233745 | pubmed:meshHeading | pubmed-meshheading:10233745... | lld:pubmed |
| pubmed-article:10233745 | pubmed:meshHeading | pubmed-meshheading:10233745... | lld:pubmed |
| pubmed-article:10233745 | pubmed:meshHeading | pubmed-meshheading:10233745... | lld:pubmed |
| pubmed-article:10233745 | pubmed:meshHeading | pubmed-meshheading:10233745... | lld:pubmed |
| pubmed-article:10233745 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10233745 | pubmed:articleTitle | T-cell anergy induced by clonotype-specific antibodies: modulation of an autoreactive human T-cell clone in vitro. | lld:pubmed |
| pubmed-article:10233745 | pubmed:affiliation | Department of Immunology, N. V. Organon, Oss, The Netherlands. | lld:pubmed |
| pubmed-article:10233745 | pubmed:publicationType | Journal Article | lld:pubmed |
