| pubmed-article:10227070 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10227070 | lifeskim:mentions | umls-concept:C0024109 | lld:lifeskim |
| pubmed-article:10227070 | lifeskim:mentions | umls-concept:C0999699 | lld:lifeskim |
| pubmed-article:10227070 | lifeskim:mentions | umls-concept:C0022009 | lld:lifeskim |
| pubmed-article:10227070 | lifeskim:mentions | umls-concept:C0006669 | lld:lifeskim |
| pubmed-article:10227070 | lifeskim:mentions | umls-concept:C0079043 | lld:lifeskim |
| pubmed-article:10227070 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:10227070 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:10227070 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:10227070 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:10227070 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:10227070 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:10227070 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:10227070 | pubmed:dateCreated | 1999-6-17 | lld:pubmed |
| pubmed-article:10227070 | pubmed:abstractText | We have studied the bronchoconstriction and the release of calcitonin gene-related peptide-like immunoreactivity induced by perfusion of pH6 buffer in the isolated guinea-pig perfused lung. Both bronchoconstriction and peptide release were completely abolished after systemic capsaicin pretreatment. Ca(2+)-free pH6 buffer infusion also completely inhibited the bronchial response, whereas the calcitonin gene-related peptide-like immunoreactivity overflow was significantly reduced. omega-Conotoxine and omega-agatoxin IVA known as N-, L- and P-type Ca2+ channel blocker, respectively, and the Na+ channel blocker tetrodotoxin decreased significantly the pH6-induced bronchial response and calcitonin gene-related peptide like immunoreactivity overflow. Nifedipine was without influence suggesting the involvement of both P- and N-type Ca2+ channel as well as the activation of an axon reflex. Ruthenium red had a more pronounced reduction effect on the functional response than on the peptide release. Ryanodine and caffeine are both agents known to influence Ca2+ release from sarcoplasmic reticulum. Ryanodine significantly reduced both bronchoconstriction and calcitonin gene-related peptide-like immunoreactivity overflow. Caffeine as well as theophylline and the Na(+)-H+ blocker, dimethylamiloride, largely depressed the functional response while producing a significant increase of calcitonin gene-related peptide-like immuno-reactivity basal value. The pH6-induced peptide overflow was slightly inhibited after caffeine and dimethylamiloride pre-treatment whereas no significant change was observed after theophylline. It is concluded that multiple ion channels including different type of Ca2+ channels appear to participate in pH6-induced bronchoconstriction and calcitonin gene-related peptide-like immunoreactivity release in the guinea-pig lung. | lld:pubmed |
| pubmed-article:10227070 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10227070 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10227070 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10227070 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10227070 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10227070 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10227070 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10227070 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10227070 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10227070 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10227070 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10227070 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:10227070 | pubmed:issn | 0901-9928 | lld:pubmed |
| pubmed-article:10227070 | pubmed:author | pubmed-author:LundbergJ MJM | lld:pubmed |
| pubmed-article:10227070 | pubmed:author | pubmed-author:LacroixJ SJS | lld:pubmed |
| pubmed-article:10227070 | pubmed:author | pubmed-author:AubersonSS | lld:pubmed |
| pubmed-article:10227070 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10227070 | pubmed:volume | 84 | lld:pubmed |
| pubmed-article:10227070 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10227070 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10227070 | pubmed:pagination | 181-6 | lld:pubmed |
| pubmed-article:10227070 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10227070 | pubmed:meshHeading | pubmed-meshheading:10227070... | lld:pubmed |
| pubmed-article:10227070 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10227070 | pubmed:articleTitle | Different ion channel control pH6-induced bronchoconstriction and calcitonin gene-related peptide release in the guinea-pig lung. | lld:pubmed |
| pubmed-article:10227070 | pubmed:affiliation | Department of Pharmacology, Karolinska Institute, Stockholm, Sweden. serge.auberson@hcuge.ch | lld:pubmed |
| pubmed-article:10227070 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10227070 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
