| pubmed-article:10223928 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10223928 | lifeskim:mentions | umls-concept:C1708335 | lld:lifeskim |
| pubmed-article:10223928 | lifeskim:mentions | umls-concept:C0031327 | lld:lifeskim |
| pubmed-article:10223928 | lifeskim:mentions | umls-concept:C0052796 | lld:lifeskim |
| pubmed-article:10223928 | lifeskim:mentions | umls-concept:C0055856 | lld:lifeskim |
| pubmed-article:10223928 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:10223928 | lifeskim:mentions | umls-concept:C0378466 | lld:lifeskim |
| pubmed-article:10223928 | lifeskim:mentions | umls-concept:C0090409 | lld:lifeskim |
| pubmed-article:10223928 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:10223928 | pubmed:dateCreated | 1999-5-27 | lld:pubmed |
| pubmed-article:10223928 | pubmed:abstractText | This randomized, open-label, crossover study was conducted to investigate whether the coadministration of zafirlukast would affect the pharmacokinetics of azithromycin, clarithromycin, or 14-hydroxyclarithromycin (14-OHC). Twelve healthy subjects (six males and six females) received single 500-mg doses of azithromycin and clarithromycin with and without zafirlukast given to a steady-state concentration. Blood was collected prior to all macrolide doses and for 3 and 10 days after each clarithromycin and azithromycin dose, respectively. Serum was assayed for azithromycin, clarithromycin, and 14-OHC concentrations by validated high-performance liquid chromatography assay systems. Data analyses were done by noncompartmental and nonparametric methods. Analysis of the patients indicated that the addition of steady-state concentrations of zafirlukast did not significantly alter the pharmacokinetic parameters of or overall exposure (based on the area under the concentration-time curve) to azithromycin, clarithromycin, and 14-OHC. While zafirlukast is a known inhibitor of CYP3A4, it does not appear to exert a clinically or statistically significant pharmacokinetic effect on azithromycin, clarithromycin, or 14-OHC. | lld:pubmed |
| pubmed-article:10223928 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10223928 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10223928 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10223928 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10223928 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10223928 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10223928 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10223928 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10223928 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10223928 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10223928 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10223928 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10223928 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10223928 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10223928 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10223928 | pubmed:month | May | lld:pubmed |
| pubmed-article:10223928 | pubmed:issn | 0066-4804 | lld:pubmed |
| pubmed-article:10223928 | pubmed:author | pubmed-author:AmsdenG WGW | lld:pubmed |
| pubmed-article:10223928 | pubmed:author | pubmed-author:PeloquinC ACA | lld:pubmed |
| pubmed-article:10223928 | pubmed:author | pubmed-author:NafzigerA NAN | lld:pubmed |
| pubmed-article:10223928 | pubmed:author | pubmed-author:GareyK WKW | lld:pubmed |
| pubmed-article:10223928 | pubmed:author | pubmed-author:GodoP GPG | lld:pubmed |
| pubmed-article:10223928 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10223928 | pubmed:volume | 43 | lld:pubmed |
| pubmed-article:10223928 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10223928 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10223928 | pubmed:pagination | 1152-5 | lld:pubmed |
| pubmed-article:10223928 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:10223928 | pubmed:meshHeading | pubmed-meshheading:10223928... | lld:pubmed |
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| pubmed-article:10223928 | pubmed:meshHeading | pubmed-meshheading:10223928... | lld:pubmed |
| pubmed-article:10223928 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10223928 | pubmed:articleTitle | Lack of effect of zafirlukast on the pharmacokinetics of azithromycin, clarithromycin, and 14-hydroxyclarithromycin in healthy volunteers. | lld:pubmed |
| pubmed-article:10223928 | pubmed:affiliation | Department of Pharmacy, Bassett Healthcare, Cooperstown, New York, USA. | lld:pubmed |
| pubmed-article:10223928 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10223928 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:10223928 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10223928 | lld:pubmed |
