| pubmed-article:10197537 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10197537 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:10197537 | lifeskim:mentions | umls-concept:C0036751 | lld:lifeskim |
| pubmed-article:10197537 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:10197537 | lifeskim:mentions | umls-concept:C0024334 | lld:lifeskim |
| pubmed-article:10197537 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:10197537 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:10197537 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:10197537 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:10197537 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:10197537 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:10197537 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:10197537 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10197537 | pubmed:dateCreated | 1999-4-27 | lld:pubmed |
| pubmed-article:10197537 | pubmed:abstractText | In order to determine the distribution and function of the 5-HT5A serotonin receptor subtype, we generated knockout mice lacking the 5-HT5A gene. Comparative autoradiography studies of brains of wild-type (wt) and 5-HT5A knockout (5A-KO) mice revealed the existence of binding sites with high affinity for [125I]LSD that correspond to 5-HT5A receptors and that are concentrated in the olfactory bulb, neocortex, and medial habenula. When exposed to novel environments, the 5A-KO mice displayed increased exploratory activity but no change in anxiety-related behaviors. In addition, the stimulatory effect of LSD on exploratory activity was attenuated in 5A-KO mice. These results suggest that 5-HT5A receptors modulate the activity of neural circuits involved specifically in exploratory behavior and suggest that some of the psychotropic effects of LSD may be mediated by 5-HT5A receptors. | lld:pubmed |
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| pubmed-article:10197537 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10197537 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10197537 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10197537 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:10197537 | pubmed:issn | 0896-6273 | lld:pubmed |
| pubmed-article:10197537 | pubmed:author | pubmed-author:GeyerM AMA | lld:pubmed |
| pubmed-article:10197537 | pubmed:author | pubmed-author:HenRR | lld:pubmed |
| pubmed-article:10197537 | pubmed:author | pubmed-author:BrunnerDD | lld:pubmed |
| pubmed-article:10197537 | pubmed:author | pubmed-author:WaeberCC | lld:pubmed |
| pubmed-article:10197537 | pubmed:author | pubmed-author:HornungJ PJP | lld:pubmed |
| pubmed-article:10197537 | pubmed:author | pubmed-author:ZhuangXX | lld:pubmed |
| pubmed-article:10197537 | pubmed:author | pubmed-author:DulawaS CSC | lld:pubmed |
| pubmed-article:10197537 | pubmed:author | pubmed-author:GrailheRR | lld:pubmed |
| pubmed-article:10197537 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10197537 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:10197537 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10197537 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10197537 | pubmed:pagination | 581-91 | lld:pubmed |
| pubmed-article:10197537 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:10197537 | pubmed:meshHeading | pubmed-meshheading:10197537... | lld:pubmed |
| pubmed-article:10197537 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10197537 | pubmed:articleTitle | Increased exploratory activity and altered response to LSD in mice lacking the 5-HT(5A) receptor. | lld:pubmed |
| pubmed-article:10197537 | pubmed:affiliation | Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA. | lld:pubmed |
| pubmed-article:10197537 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10197537 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10197537 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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