Linked Life Data

10195640

Source:http://linkedlifedata.com/resource/pubmed/id/10195640

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pubmed-article:10195640pubmed:abstractTextThree recombinant strains of Mycobacterium bovis Bacille Calmette Guerin (rBCG) were prepared in which the immunogenic B subunit of human Escherichia coli heat labile enterotoxin (LT-Bh) was expressed either as a cytoplasm protein, a cell wall associated lipoprotein or a secreted protein. Intraperitoneal immunisation of mice with these rBCG induced IgG and IgA antibodies to LT-Bh and shifted the serum IgG subclass response to subsequent challenge with purified LT-Bh from IgG1 to an IgG2a. Oral administration of recombinant BCG induced mucosal and serum IgA antibodies to LT-Bh which peaked four months after immunisation. Antibody responses were greater when LT-Bh was expressed as a secreted protein or lipoprotein rather than in the cytoplasm. Oral vaccination with recombinant BCG may be an effective approach, particularly to induce mucosal IgA and prime for a serum TH1 recall response.lld:pubmed
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pubmed-article:10195640pubmed:articleTitleConstruction and murine immunogenicity of recombinant Bacille Calmette Guérin vaccines expressing the B subunit of Escherichia coli heat labile enterotoxin.lld:pubmed
pubmed-article:10195640pubmed:affiliationDivision of Infectious Diseases, St. George's Hospital Medical School, London, UK.lld:pubmed
pubmed-article:10195640pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10195640pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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