| pubmed-article:10103062 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10103062 | lifeskim:mentions | umls-concept:C0029246 | lld:lifeskim |
| pubmed-article:10103062 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:10103062 | lifeskim:mentions | umls-concept:C1418833 | lld:lifeskim |
| pubmed-article:10103062 | lifeskim:mentions | umls-concept:C0679058 | lld:lifeskim |
| pubmed-article:10103062 | lifeskim:mentions | umls-concept:C1514468 | lld:lifeskim |
| pubmed-article:10103062 | lifeskim:mentions | umls-concept:C1547699 | lld:lifeskim |
| pubmed-article:10103062 | lifeskim:mentions | umls-concept:C1552848 | lld:lifeskim |
| pubmed-article:10103062 | lifeskim:mentions | umls-concept:C2700640 | lld:lifeskim |
| pubmed-article:10103062 | lifeskim:mentions | umls-concept:C1523987 | lld:lifeskim |
| pubmed-article:10103062 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10103062 | pubmed:dateCreated | 1999-5-19 | lld:pubmed |
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| pubmed-article:10103062 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10103062 | pubmed:abstractText | Nuclear inhibitor of protein phosphatase-1 (NIPP-1) is one of two major regulatory subunits of protein phosphatase-1 in mammalian nuclei. We report here the cloning and structural characterization of the human NIPP-1 genes, designated PPP1R8P and PPP1R8 in human gene nomenclature. PPP1R8P (1.2 kb) is a processed pseudogene and was localized by in situ hybridization to chromosome 1p33-32. PPP1R8 is an authentic NIPP-1 gene and was localized to chromosome 1p35. PPP1R8 (25.2 kb) is composed of seven exons and encodes four different transcripts, as determined from cDNA library screening, reverse transcriptase-PCR (RT-PCR) and/or EST (expressed sequence tag) database search analysis. NIPP-1alpha mRNA represents the major transcript in human tissues and various cell lines, and encodes a polypeptide of 351 residues that only differs from the previously cloned calf thymus NIPP-1 by a single residue. The other transcripts, termed NIPP-1beta, gamma and delta, are generated by alternative 5'-splice site usage, by exon skipping and/or by alternative polyadenylation. The NIPP-1beta/delta and NIPP-1gamma mRNAs are expected to encode fragments of NIPP-1alpha that differ from the latter by the absence of the first 142 and 224 residues, respectively. NIPP-1gamma corresponds to 'activator of RNA decay-1' (Ard-1) which, unlike NIPP-1alpha, displays in vitro and endoribonuclease activity and lacks an RVXF consensus motif for interaction with protein phosphatase-1. While the NIPP-1alpha/beta/delta-transcripts were found to be present in various human tissues, the NIPP-1gamma transcript could only be detected in human transformed B-lymphocytes. | lld:pubmed |
| pubmed-article:10103062 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10103062 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10103062 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10103062 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10103062 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10103062 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10103062 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10103062 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10103062 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10103062 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10103062 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10103062 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10103062 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10103062 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10103062 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10103062 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10103062 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10103062 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:10103062 | pubmed:issn | 0014-2956 | lld:pubmed |
| pubmed-article:10103062 | pubmed:author | pubmed-author:StalmansWW | lld:pubmed |
| pubmed-article:10103062 | pubmed:author | pubmed-author:BollerAA | lld:pubmed |
| pubmed-article:10103062 | pubmed:author | pubmed-author:Van EyndeAA | lld:pubmed |
| pubmed-article:10103062 | pubmed:author | pubmed-author:SchoenmakersE... | lld:pubmed |
| pubmed-article:10103062 | pubmed:author | pubmed-author:JacqueminMM | lld:pubmed |
| pubmed-article:10103062 | pubmed:author | pubmed-author:Pérez-Callejó... | lld:pubmed |
| pubmed-article:10103062 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10103062 | pubmed:volume | 261 | lld:pubmed |
| pubmed-article:10103062 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10103062 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10103062 | pubmed:pagination | 291-300 | lld:pubmed |
| pubmed-article:10103062 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:10103062 | pubmed:meshHeading | pubmed-meshheading:10103062... | lld:pubmed |
| pubmed-article:10103062 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10103062 | pubmed:articleTitle | Organization and alternate splice products of the gene encoding nuclear inhibitor of protein phosphatase-1 (NIPP-1). | lld:pubmed |
| pubmed-article:10103062 | pubmed:affiliation | Afdeling Biochemie, Campus Gasthuisberg KULeuven, Herestraat 49, B-3000 Leuven, Belgium. | lld:pubmed |
| pubmed-article:10103062 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10103062 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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