| pubmed-article:10097084 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10097084 | lifeskim:mentions | umls-concept:C1707310 | lld:lifeskim |
| pubmed-article:10097084 | lifeskim:mentions | umls-concept:C1709060 | lld:lifeskim |
| pubmed-article:10097084 | lifeskim:mentions | umls-concept:C2827481 | lld:lifeskim |
| pubmed-article:10097084 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:10097084 | pubmed:dateCreated | 1999-5-12 | lld:pubmed |
| pubmed-article:10097084 | pubmed:abstractText | A vaccinia virus-based RNA expression system enabled high-level cytoplasmic expression of RNA aptamers directed against the intracellular domain of the beta2 integrin LFA-1, a transmembrane protein that mediates cell adhesion to intercellular adhesion molecule-1 (ICAM-1). In two different cell types, cytoplasmic expression of integrin-binding aptamers reduced inducible cell adhesion to ICAM-1. The aptamers specifically target, and thereby define, a functional cytoplasmic subdomain important for the regulation of cell adhesion in leukocytes. Our approach of aptamer-controlled blocking of signaling pathways in vivo could potentially be applied wherever targeted modulation of a signal-transduction cascade is desired. | lld:pubmed |
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| pubmed-article:10097084 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10097084 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10097084 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10097084 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:10097084 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:10097084 | pubmed:author | pubmed-author:BlinkDD | lld:pubmed |
| pubmed-article:10097084 | pubmed:author | pubmed-author:KolanusWW | lld:pubmed |
| pubmed-article:10097084 | pubmed:author | pubmed-author:FamulokMM | lld:pubmed |
| pubmed-article:10097084 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10097084 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:10097084 | pubmed:volume | 96 | lld:pubmed |
| pubmed-article:10097084 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10097084 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10097084 | pubmed:pagination | 3606-10 | lld:pubmed |
| pubmed-article:10097084 | pubmed:dateRevised | 2010-9-10 | lld:pubmed |
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| pubmed-article:10097084 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10097084 | pubmed:articleTitle | Cytoplasmic RNA modulators of an inside-out signal-transduction cascade. | lld:pubmed |
| pubmed-article:10097084 | pubmed:affiliation | Institut für Biochemie, Ludwig-Maximilians-Universität Munich, Feodor-Lynen-Strasse 25, 81377 Munich, Germany. | lld:pubmed |
| pubmed-article:10097084 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10097084 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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