| pubmed-article:10087340 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10087340 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:10087340 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:10087340 | lifeskim:mentions | umls-concept:C1179517 | lld:lifeskim |
| pubmed-article:10087340 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:10087340 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:10087340 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:10087340 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:10087340 | lifeskim:mentions | umls-concept:C1550548 | lld:lifeskim |
| pubmed-article:10087340 | lifeskim:mentions | umls-concept:C1555714 | lld:lifeskim |
| pubmed-article:10087340 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:10087340 | lifeskim:mentions | umls-concept:C1705294 | lld:lifeskim |
| pubmed-article:10087340 | lifeskim:mentions | umls-concept:C1705654 | lld:lifeskim |
| pubmed-article:10087340 | lifeskim:mentions | umls-concept:C0599668 | lld:lifeskim |
| pubmed-article:10087340 | pubmed:dateCreated | 1999-6-29 | lld:pubmed |
| pubmed-article:10087340 | pubmed:abstractText | 1. We have studied capacitative calcium entry (CCE) under different experimental conditions in fura-2-loaded mouse pancreatic acinar cells by digital microscopic fluorimetry. CCE was investigated during [Ca2+]i decay after cell stimulation with a supramaximal concentration of ACh (10 microM) or during Ca2+ readmission in Ca2+-depleted cells (pretreated with thapsigargin or ACh). 2. La3+ and Zn2+ (100 microM) inhibited CCE during Ca2+ readmission but had negligible effects during ACh decay. In contrast flufenamic acid (100 microM), an inhibitor of non-selective cation channels, genistein (10 microM), a broad-range tyrosine kinase inhibitor, and piceatannol (10 microM), an inhibitor specific for non-receptor Syk tyrosine kinase, inhibited CCE during ACh decay but not during Ca2+ reintroduction. 3. Simultaneous detection of Mn2+ entry and [Ca2+]i measurement showed that, in the presence of extracellular calcium, application of 100 microM Mn2+ during ACh decay resulted in manganese influx without alteration of calcium influx, whilst when applied during Ca2+ readmission, Mn2+ entry was significantly smaller and induced a clear inhibition of CCE. 4. Application of the specific protein kinase C inhibitor GF109293X (3 microM) reduced CCE in Ca2+-depleted cells, whereas the activator phorbol 12-myristate, 13-acetate (3 microM) increased Ca2+ entry. 5. Based on these results we propose that cholinergic stimulation of mouse pancreatic acinar cells induces Ca2+ influx with an initial phase operated by a non-specific cation channel, sensitive to flufenamic acid and tyrosine kinase inhibitors but insensitive to lanthanum and divalent cations, followed by a moderately Ca2+-selective conductance inhibited by lanthanum and divalent cations. | lld:pubmed |
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| pubmed-article:10087340 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10087340 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10087340 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10087340 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10087340 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10087340 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:10087340 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:10087340 | pubmed:author | pubmed-author:SalidoG MGM | lld:pubmed |
| pubmed-article:10087340 | pubmed:author | pubmed-author:ParienteJ AJA | lld:pubmed |
| pubmed-article:10087340 | pubmed:author | pubmed-author:CamelloP JPJ | lld:pubmed |
| pubmed-article:10087340 | pubmed:author | pubmed-author:CamelloCC | lld:pubmed |
| pubmed-article:10087340 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10087340 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:10087340 | pubmed:volume | 516 ( Pt 2) | lld:pubmed |
| pubmed-article:10087340 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10087340 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10087340 | pubmed:pagination | 399-408 | lld:pubmed |
| pubmed-article:10087340 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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