| pubmed-article:10087184 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10087184 | lifeskim:mentions | umls-concept:C0262950 | lld:lifeskim |
| pubmed-article:10087184 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:10087184 | lifeskim:mentions | umls-concept:C0333348 | lld:lifeskim |
| pubmed-article:10087184 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:10087184 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:10087184 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:10087184 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10087184 | pubmed:dateCreated | 1999-4-29 | lld:pubmed |
| pubmed-article:10087184 | pubmed:abstractText | Although cytokines and other soluble regulators of immunity are known to be involved in hematopoiesis, little is known about the signals that induce the synthesis of those mediators locally. Based on recent studies linking the neuroendocrine hormone thyrotropin [thyroid-stimulating hormone (TSH)] to immune cell function in other tissues, we investigated the capacity of TSH to activate cytokine responses from bone marrow cells. These studies reveal that stimulation of the TSH receptor on bone marrow cells-using highly purified or recombinant TSH or by direct stimulation with anti-TSH receptor antibodies-rapidly induces the synthesis of cytokines from bone marrow cells that are classically used in the regulation of inflammatory responses. Of 13 cytokines screened for activity by ELISA or by RNase protection assays for gene expression, IL-6, IFN-beta, TNFalpha, TNFbeta, TGFbeta2, and lymphotoxin-beta responses were reproducibly induced by TSH within 2-3 h of stimulation. Intracellularly, TSH stimulation of bone marrow cells caused rapid increases in cAMP levels and induced the phosphorylation of the Jak2 protein kinase, thereby defining a novel G-protein-coupled receptor/cytokine synthesis pathway. These findings demonstrate that TSH can serve as a primary inductive signal of cytokine production by bone marrow cells. | lld:pubmed |
| pubmed-article:10087184 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10087184 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10087184 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10087184 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10087184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10087184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10087184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10087184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10087184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10087184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10087184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10087184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10087184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10087184 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10087184 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:10087184 | pubmed:issn | 0008-8749 | lld:pubmed |
| pubmed-article:10087184 | pubmed:author | pubmed-author:KleinJ RJR | lld:pubmed |
| pubmed-article:10087184 | pubmed:author | pubmed-author:PrabhakarB... | lld:pubmed |
| pubmed-article:10087184 | pubmed:author | pubmed-author:WhetsellMM | lld:pubmed |
| pubmed-article:10087184 | pubmed:author | pubmed-author:Seetharamaiah... | lld:pubmed |
| pubmed-article:10087184 | pubmed:author | pubmed-author:BagriacikE... | lld:pubmed |
| pubmed-article:10087184 | pubmed:copyrightInfo | Copyright 1999 Academic Press. | lld:pubmed |
| pubmed-article:10087184 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10087184 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:10087184 | pubmed:volume | 192 | lld:pubmed |
| pubmed-article:10087184 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10087184 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10087184 | pubmed:pagination | 159-66 | lld:pubmed |
| pubmed-article:10087184 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:10087184 | pubmed:meshHeading | pubmed-meshheading:10087184... | lld:pubmed |
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| pubmed-article:10087184 | pubmed:meshHeading | pubmed-meshheading:10087184... | lld:pubmed |
| pubmed-article:10087184 | pubmed:meshHeading | pubmed-meshheading:10087184... | lld:pubmed |
| pubmed-article:10087184 | pubmed:meshHeading | pubmed-meshheading:10087184... | lld:pubmed |
| pubmed-article:10087184 | pubmed:meshHeading | pubmed-meshheading:10087184... | lld:pubmed |
| pubmed-article:10087184 | pubmed:meshHeading | pubmed-meshheading:10087184... | lld:pubmed |
| pubmed-article:10087184 | pubmed:meshHeading | pubmed-meshheading:10087184... | lld:pubmed |
| pubmed-article:10087184 | pubmed:meshHeading | pubmed-meshheading:10087184... | lld:pubmed |
| pubmed-article:10087184 | pubmed:meshHeading | pubmed-meshheading:10087184... | lld:pubmed |
| pubmed-article:10087184 | pubmed:meshHeading | pubmed-meshheading:10087184... | lld:pubmed |
| pubmed-article:10087184 | pubmed:meshHeading | pubmed-meshheading:10087184... | lld:pubmed |
| pubmed-article:10087184 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10087184 | pubmed:articleTitle | Neuroendocrine-induced synthesis of bone marrow-derived cytokines with inflammatory immunomodulating properties. | lld:pubmed |
| pubmed-article:10087184 | pubmed:affiliation | Department of Biological Science and the Mervin Bovaird Center for Studies in Molecular Biology and Biotechnology, University of Tulsa, Tulsa, Oklahoma 74104, USA. | lld:pubmed |
| pubmed-article:10087184 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10087184 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10087184 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10087184 | lld:pubmed |
