| pubmed-article:10086329 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10086329 | lifeskim:mentions | umls-concept:C0043188 | lld:lifeskim |
| pubmed-article:10086329 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:10086329 | lifeskim:mentions | umls-concept:C0034392 | lld:lifeskim |
| pubmed-article:10086329 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:10086329 | lifeskim:mentions | umls-concept:C0001884 | lld:lifeskim |
| pubmed-article:10086329 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:10086329 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10086329 | lifeskim:mentions | umls-concept:C0073096 | lld:lifeskim |
| pubmed-article:10086329 | lifeskim:mentions | umls-concept:C1709843 | lld:lifeskim |
| pubmed-article:10086329 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:10086329 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:10086329 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:10086329 | pubmed:dateCreated | 1999-4-1 | lld:pubmed |
| pubmed-article:10086329 | pubmed:abstractText | The beneficial effects of moderate red wine consumption have been attributed, in part, to the presence of antioxidant components. Oxidant stress is an activating stimulus for the NF (nuclear factor)-KB/Rel family of transcription factors, which have binding sites in the promoter regions of many genes involved in inflammatory and immune responses. The effect of lipopolysaccharide (LPS)-stimulated activation of NF-KB and the subsequent production of tumor necrosis factor alpha (TNF-alpha) and NO was determined in the macrophage cell line RAW 264.7. Unexpectedly, the wine polyphenolics quercetin and resveratrol and the antioxidant N-acetylcysteine (NAC) did not inhibit LPS-induced activation of the NF-KB complex p50/65, as determined by mobility shift. Quercetin inhibited LPS-induced p50/50. Northern blot analysis indicated that quercetin (0.1 and 0.2 mM) inhibited LPS-dependent production of inducible nitric oxide synthase (iNOS) mRNA and decreased NO release, as measured by the Griess reaction. This flavonoid had no effect on LPS-induced TNF-alpha mRNA, but decreased LPS-stimulated TNF-alpha release, as measured by ELISA. Resveratrol (0.05 and 0.1 mM) posttranscriptionally decreased LPS-induced nitrite release. It increased basal levels of TNF-alpha mRNA and protein and enhanced LPS-induced TNF-alpha mRNA and cytokine release. Our results do not support the view that wine antioxidants inhibit LPS-induced NF-KB activation but instead that they have a more selective action on genes activated by LPS. | lld:pubmed |
| pubmed-article:10086329 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10086329 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10086329 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10086329 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10086329 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:10086329 | pubmed:issn | 0006-2952 | lld:pubmed |
| pubmed-article:10086329 | pubmed:author | pubmed-author:KoopD RDR | lld:pubmed |
| pubmed-article:10086329 | pubmed:author | pubmed-author:WadsworthT... | lld:pubmed |
| pubmed-article:10086329 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10086329 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:10086329 | pubmed:volume | 57 | lld:pubmed |
| pubmed-article:10086329 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10086329 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10086329 | pubmed:pagination | 941-9 | lld:pubmed |
| pubmed-article:10086329 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:10086329 | pubmed:meshHeading | pubmed-meshheading:10086329... | lld:pubmed |
| pubmed-article:10086329 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10086329 | pubmed:articleTitle | Effects of the wine polyphenolics quercetin and resveratrol on pro-inflammatory cytokine expression in RAW 264.7 macrophages. | lld:pubmed |
| pubmed-article:10086329 | pubmed:affiliation | Department of Physiology and Pharmacology, Oregon Health Sciences University, Portland 97201, USA. | lld:pubmed |
| pubmed-article:10086329 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10086329 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10086329 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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