| pubmed-article:10069411 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10069411 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:10069411 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:10069411 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:10069411 | lifeskim:mentions | umls-concept:C0020964 | lld:lifeskim |
| pubmed-article:10069411 | lifeskim:mentions | umls-concept:C0041221 | lld:lifeskim |
| pubmed-article:10069411 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:10069411 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:10069411 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:10069411 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10069411 | pubmed:dateCreated | 1999-8-17 | lld:pubmed |
| pubmed-article:10069411 | pubmed:abstractText | Trypanosoma cruzi was transformed with the Plasmodium yoelii gene encoding the circum-sporozoite (CS) protein, which contains the well-characterized CD8+ T cell epitope, SYVPSAEQI. In vivo and in vitro assays indicated that cells infected with the transformed T. cruzi could process and present this malaria parasite-derived class I MHC-restricted epitope. Immunization of mice with recombinant influenza and vaccinia viruses expressing the SYVPSAEQI epitope induced a large number of specific CD8+ T cells that strongly suppressed parasitemia and conferred complete protection against the acute T. cruzi lethal infection. CD8+ T cells mediated this immunity as indicated by the unrelenting parasitemia and high mortality observed in immunized mice treated with anti-CD8 antibody. This study demonstrated, for the first time, that vaccination of mice with vectors designed to induce CD8+ T cells is effective against T. cruzi infection. | lld:pubmed |
| pubmed-article:10069411 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10069411 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10069411 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10069411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10069411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10069411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10069411 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10069411 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10069411 | pubmed:issn | 0953-8178 | lld:pubmed |
| pubmed-article:10069411 | pubmed:author | pubmed-author:KobayashiSS | lld:pubmed |
| pubmed-article:10069411 | pubmed:author | pubmed-author:TakeuchiTT | lld:pubmed |
| pubmed-article:10069411 | pubmed:author | pubmed-author:NaraTT | lld:pubmed |
| pubmed-article:10069411 | pubmed:author | pubmed-author:AokiTT | lld:pubmed |
| pubmed-article:10069411 | pubmed:author | pubmed-author:KamiyamaTT | lld:pubmed |
| pubmed-article:10069411 | pubmed:author | pubmed-author:MiyahiraYY | lld:pubmed |
| pubmed-article:10069411 | pubmed:author | pubmed-author:Nakajima-Shim... | lld:pubmed |
| pubmed-article:10069411 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10069411 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:10069411 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10069411 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10069411 | pubmed:pagination | 133-41 | lld:pubmed |
| pubmed-article:10069411 | pubmed:dateRevised | 2006-4-21 | lld:pubmed |
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| pubmed-article:10069411 | pubmed:meshHeading | pubmed-meshheading:10069411... | lld:pubmed |
| pubmed-article:10069411 | pubmed:meshHeading | pubmed-meshheading:10069411... | lld:pubmed |
| pubmed-article:10069411 | pubmed:meshHeading | pubmed-meshheading:10069411... | lld:pubmed |
| pubmed-article:10069411 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10069411 | pubmed:articleTitle | Induction of CD8+ T cell-mediated protective immunity against Trypanosoma cruzi. | lld:pubmed |
| pubmed-article:10069411 | pubmed:affiliation | Department of Parasitology, Juntendo University School of Medicine, Tokyo, Japan. | lld:pubmed |
| pubmed-article:10069411 | pubmed:publicationType | Journal Article | lld:pubmed |
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