Linked Life Data

10050867

Source:http://linkedlifedata.com/resource/pubmed/id/10050867

Statements in which the resource exists.
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pubmed-article:10050867pubmed:abstractTextMost human female cells contain two X chromosomes, only one of which is active. The process of X-chromosome inactivation, which occurs early in development, is usually random, producing tissues with equal mixtures of cells having active X chromosomes of either maternal or paternal origin. However, nonrandom inactivation may occur in a subset of females. If a tumor suppressor gene were located on the X chromosome and if females with a germline mutation in one copy of that suppressor gene experienced nonrandom X-chromosome inactivation, then some or all of the tissues of such women might lack the wild-type suppressor gene function. This scenario could represent a previously unrecognized mechanism for development of hereditary cancers. We investigated whether such a mechanism might contribute to the development of hereditary ovarian cancers.lld:pubmed
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pubmed-article:10050867pubmed:authorpubmed-author:SoodA KAKlld:pubmed
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pubmed-article:10050867pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:10050867pubmed:articleTitleAssociation between nonrandom X-chromosome inactivation and BRCA1 mutation in germline DNA of patients with ovarian cancer.lld:pubmed
pubmed-article:10050867pubmed:affiliationDepartment of Pharmacology, The University of Iowa Hospitals and Clinics, Iowa City 52242-1009, USA. richard-buller@uiowa.edulld:pubmed
pubmed-article:10050867pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10050867pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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