| pubmed-article:10037683 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10037683 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10037683 | lifeskim:mentions | umls-concept:C0004381 | lld:lifeskim |
| pubmed-article:10037683 | lifeskim:mentions | umls-concept:C0206588 | lld:lifeskim |
| pubmed-article:10037683 | lifeskim:mentions | umls-concept:C0031412 | lld:lifeskim |
| pubmed-article:10037683 | lifeskim:mentions | umls-concept:C1420354 | lld:lifeskim |
| pubmed-article:10037683 | lifeskim:mentions | umls-concept:C1382176 | lld:lifeskim |
| pubmed-article:10037683 | lifeskim:mentions | umls-concept:C1413828 | lld:lifeskim |
| pubmed-article:10037683 | lifeskim:mentions | umls-concept:C1417827 | lld:lifeskim |
| pubmed-article:10037683 | lifeskim:mentions | umls-concept:C1553423 | lld:lifeskim |
| pubmed-article:10037683 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:10037683 | pubmed:dateCreated | 1999-3-30 | lld:pubmed |
| pubmed-article:10037683 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10037683 | pubmed:abstractText | The endogenous CYP2B6 gene becomes phenobarbital (PB) inducible in androstenol-treated HepG2 cells either transiently or stably transfected with a nuclear receptor CAR expression vector. The PB induction mediated by CAR is regulated by a conserved 51-base pair element called PB-responsive enhancer module (PBREM) that has now been located between -1733 and -1683 bp in the gene's 5'-flanking region. An in vitro translated CAR acting as a retinoid X receptor alpha heterodimer binds directly to the two nuclear receptor sites NR1 and NR2 within PBREM. In a stably transfected HepG2 cell line, both PBREM and NR1 are activated by PB and PB-type compounds such as chlorinated pesticides, polychlorinated biphenyls and chlorpromazine. In addition to PBREM, CAR also transactivates the steroid/rifampicin-response element of the human CYP3A4 gene in HepG2 cells. Thus, activation of the repressed nuclear receptor CAR appears to be a versatile mediator that regulates PB induction of the CYP2B and other genes. | lld:pubmed |
| pubmed-article:10037683 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10037683 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10037683 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10037683 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:10037683 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:10037683 | pubmed:author | pubmed-author:NegishiMM | lld:pubmed |
| pubmed-article:10037683 | pubmed:author | pubmed-author:KawamotoTT | lld:pubmed |
| pubmed-article:10037683 | pubmed:author | pubmed-author:SueyoshiTT | lld:pubmed |
| pubmed-article:10037683 | pubmed:author | pubmed-author:HonkakoskiPP | lld:pubmed |
| pubmed-article:10037683 | pubmed:author | pubmed-author:ZelkoII | lld:pubmed |
| pubmed-article:10037683 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10037683 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:10037683 | pubmed:volume | 274 | lld:pubmed |
| pubmed-article:10037683 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10037683 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10037683 | pubmed:pagination | 6043-6 | lld:pubmed |
| pubmed-article:10037683 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10037683 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10037683 | pubmed:articleTitle | The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene. | lld:pubmed |
| pubmed-article:10037683 | pubmed:affiliation | Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. | lld:pubmed |
| pubmed-article:10037683 | pubmed:publicationType | Journal Article | lld:pubmed |
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