| pubmed-article:9973198 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9973198 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9973198 | lifeskim:mentions | umls-concept:C1513095 | lld:lifeskim |
| pubmed-article:9973198 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:9973198 | lifeskim:mentions | umls-concept:C0085862 | lld:lifeskim |
| pubmed-article:9973198 | lifeskim:mentions | umls-concept:C1299583 | lld:lifeskim |
| pubmed-article:9973198 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:9973198 | lifeskim:mentions | umls-concept:C1160191 | lld:lifeskim |
| pubmed-article:9973198 | lifeskim:mentions | umls-concept:C1608386 | lld:lifeskim |
| pubmed-article:9973198 | lifeskim:mentions | umls-concept:C1549571 | lld:lifeskim |
| pubmed-article:9973198 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9973198 | pubmed:dateCreated | 1999-2-25 | lld:pubmed |
| pubmed-article:9973198 | pubmed:abstractText | Increased production of transforming growth factor beta (TGF-beta) coupled with resistance to the growth-inhibitory effects of TGF-beta is characteristic of several types of neoplasia including human melanoma. In select epithelial malignancies, lack of TGF-beta-induced growth inhibition is associated with disruptions of TGF-beta-dependent SMAD signaling and transcription. In contrast, the results of the present study indicate intact SMAD-dependent transcription in human melanoma cells, regardless of their proliferative response to exogenous TGF-beta. Furthermore, in some melanoma cell lines constitutive SMAD-dependent transcription was observed, which was due in part to endogenous TGF-beta. These results establish that resistance of melanoma cells to TGF-beta-induced growth inhibition occurs independently of intact TGF-beta receptor/SMAD-mediated transcriptional regulation. They also suggest that melanoma-derived TGF-beta may exert autocrine effects on SMAD-sensitive target genes. | lld:pubmed |
| pubmed-article:9973198 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9973198 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9973198 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9973198 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9973198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9973198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9973198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9973198 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9973198 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9973198 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:9973198 | pubmed:author | pubmed-author:NishiyamaTT | lld:pubmed |
| pubmed-article:9973198 | pubmed:author | pubmed-author:MauvielAA | lld:pubmed |
| pubmed-article:9973198 | pubmed:author | pubmed-author:RodeckUU | lld:pubmed |
| pubmed-article:9973198 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9973198 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9973198 | pubmed:volume | 59 | lld:pubmed |
| pubmed-article:9973198 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9973198 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9973198 | pubmed:pagination | 547-50 | lld:pubmed |
| pubmed-article:9973198 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:9973198 | pubmed:meshHeading | pubmed-meshheading:9973198-... | lld:pubmed |
| pubmed-article:9973198 | pubmed:meshHeading | pubmed-meshheading:9973198-... | lld:pubmed |
| pubmed-article:9973198 | pubmed:meshHeading | pubmed-meshheading:9973198-... | lld:pubmed |
| pubmed-article:9973198 | pubmed:meshHeading | pubmed-meshheading:9973198-... | lld:pubmed |
| pubmed-article:9973198 | pubmed:meshHeading | pubmed-meshheading:9973198-... | lld:pubmed |
| pubmed-article:9973198 | pubmed:meshHeading | pubmed-meshheading:9973198-... | lld:pubmed |
| pubmed-article:9973198 | pubmed:meshHeading | pubmed-meshheading:9973198-... | lld:pubmed |
| pubmed-article:9973198 | pubmed:meshHeading | pubmed-meshheading:9973198-... | lld:pubmed |
| pubmed-article:9973198 | pubmed:meshHeading | pubmed-meshheading:9973198-... | lld:pubmed |
| pubmed-article:9973198 | pubmed:meshHeading | pubmed-meshheading:9973198-... | lld:pubmed |
| pubmed-article:9973198 | pubmed:meshHeading | pubmed-meshheading:9973198-... | lld:pubmed |
| pubmed-article:9973198 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:9973198 | pubmed:articleTitle | Independent regulation of growth and SMAD-mediated transcription by transforming growth factor beta in human melanoma cells. | lld:pubmed |
| pubmed-article:9973198 | pubmed:affiliation | Department of Dermatology and Cutaneous Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. | lld:pubmed |
| pubmed-article:9973198 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9973198 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9973198 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9973198 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9973198 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9973198 | lld:pubmed |
