| pubmed-article:9973196 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9973196 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9973196 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:9973196 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:9973196 | lifeskim:mentions | umls-concept:C0013935 | lld:lifeskim |
| pubmed-article:9973196 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
| pubmed-article:9973196 | lifeskim:mentions | umls-concept:C0009498 | lld:lifeskim |
| pubmed-article:9973196 | lifeskim:mentions | umls-concept:C0006556 | lld:lifeskim |
| pubmed-article:9973196 | lifeskim:mentions | umls-concept:C0879389 | lld:lifeskim |
| pubmed-article:9973196 | lifeskim:mentions | umls-concept:C1155661 | lld:lifeskim |
| pubmed-article:9973196 | lifeskim:mentions | umls-concept:C0243067 | lld:lifeskim |
| pubmed-article:9973196 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9973196 | pubmed:dateCreated | 1999-2-25 | lld:pubmed |
| pubmed-article:9973196 | pubmed:abstractText | The DNA mismatch repair gene hMLH1 is reported to function in mutation avoidance, cell cycle checkpoint control, the cytotoxicity of various DNA-damaging agents, and transcription-coupled nucleotide excision repair. Formal proof of the involvement of hMLH1 in these processes requires single gene complementation. We have stably expressed hMLH1 from a transfected cDNA in Mlh1-deficient mouse embryonic fibroblasts. Expression of hMLH1 restored normal levels of mPMS2 protein, reduced spontaneous base substitution and microsatellite mutations, increased sensitivity to the toxic effects of 6-thioguanine (6-TG), and restored 6-TG-induced cell cycle arrest. Our studies confirm that hMLH1 has an essential role in the maintenance of genomic stability and the potentiation of 6-TG cytotoxicity and provide a system for detailed structure/function analysis of the hMLH1 protein. | lld:pubmed |
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| pubmed-article:9973196 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9973196 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9973196 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9973196 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9973196 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:9973196 | pubmed:author | pubmed-author:LiskayR MRM | lld:pubmed |
| pubmed-article:9973196 | pubmed:author | pubmed-author:BakerS MSM | lld:pubmed |
| pubmed-article:9973196 | pubmed:author | pubmed-author:BuermeyerA... | lld:pubmed |
| pubmed-article:9973196 | pubmed:author | pubmed-author:Wilson-Van... | lld:pubmed |
| pubmed-article:9973196 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9973196 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9973196 | pubmed:volume | 59 | lld:pubmed |
| pubmed-article:9973196 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9973196 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9973196 | pubmed:pagination | 538-41 | lld:pubmed |
| pubmed-article:9973196 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:9973196 | pubmed:meshHeading | pubmed-meshheading:9973196-... | lld:pubmed |
| pubmed-article:9973196 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:9973196 | pubmed:articleTitle | The human MLH1 cDNA complements DNA mismatch repair defects in Mlh1-deficient mouse embryonic fibroblasts. | lld:pubmed |
| pubmed-article:9973196 | pubmed:affiliation | Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201-3098, USA. | lld:pubmed |
| pubmed-article:9973196 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9973196 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9973196 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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